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Detection of follistatin-based inhibitors of the TGF-β signaling pathways in serum/plasma by means of LC-HRMS/MS & Western blotting.
Drug Testing and Analysis ( IF 2.9 ) Pub Date : 2020-09-22 , DOI: 10.1002/dta.2925
Katja Walpurgis 1 , Tim Weigand 1 , Andre Knoop 1 , Andreas Thomas 1 , Christian Reichel 2 , Frank Dellanna 3 , Mario Thevis 1, 4
Affiliation  

Cytokines of the transforming growth factor beta (TGF‐β) superfamily such as myostatin and activin A are considered as key regulators of skeletal muscle mass. In vivo, their activity is controlled by different binding proteins such as follistatin (FST), whose interaction with the circulating growth factors prevents activation of the activin type II receptors. FST‐based protein therapeutics are therefore not only promising drug candidates for the treatment of muscular diseases but also potential performance‐enhancing agents in sports.

中文翻译:

通过 LC-HRMS/MS 和蛋白质印迹法检测血清/血浆中基于卵泡抑素的 TGF-β 信号通路抑制剂。

转化生长因子β(TGF-β)超家族的细胞因子,如肌生长抑制素和激活素 A,被认为是骨骼肌质量的关键调节剂。在体内,它们的活性受不同结合蛋白的控制,例如卵泡抑素 (FST),其与循环生长因子的相互作用会阻止激活素 II 型受体的激活。因此,基于 FST 的蛋白质疗法不仅是治疗肌肉疾病的有希望的候选药物,而且是潜在的运动表现增强剂。
更新日期:2020-09-22
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