To investigate intrinsic physicochemical properties and interactions of three different calcium hydroxide‐based medications via means of different analytical methods. Two‐commercial premixed medications: TempCanal(TCmx) and ProCalR(PCmx) and powder‐form ProCal(PCpw) with glycerin were used. Vibrational modes were analyzed using Raman spectroscopy. Spectral mapping of samples was carried out using characteristic vibrational modes of calcium hydroxide and barium sulfate. Crystalline and amorphous phases were studied with X‐rays powder diffraction analysis. Topographic features were examined by scanning electron microscope examination and quantitative analysis was determined using energy‐dispersive X‐ray spectroscopy analysis. Strong OH stretch of in Raman spectra were observed at 3,697 and 3,615 cm⁻¹ for TCmx and reference, respectively. However, OH mode was not observed for PCmx and PCpw. Moreover, some peaks in the fingerprint areas of TCmx and PCpw overlapped with each other. The characteristic vibration bands of barium sulfate and calcium hydroxide were observed in all samples, and no new peak was observed in the Raman spectra of samples. Calcium hydroxide‐based medications were seen as differed in their chemical composition. No new crystalline or amorphous phase peak was observed. Only calcium hydroxide and barium sulfate were matched in X‐rays powder‐diffraction analysis. Energy‐dispersive X‐ray spectroscopy analysis showed that amount of Ba and S elements in the PCpw were lower than TCmx and PCmx whereas, for Ca in the PCpw was higher than TCmx and PCmx. The present study revealed the structural difference among different forms of calcium hydroxide‐based medications. The vehicle and substrates of the tested medications altered the physicochemical properties of the compound via electrostatic interactions.

中文翻译：

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氢氧化钙基药物的内在理化相互作用

通过不同的分析方法研究三种不同的基于氢氧化钙的药物的内在理化性质和相互作用。使用两种商品的预混药物：TempCanal（TCmx）和ProCalR（PCmx）以及粉末形式的ProCal（PCpw）和甘油。使用拉曼光谱分析振动模式。使用氢氧化钙和硫酸钡的特征振动模式对样品进行光谱作图。X射线粉末衍射分析研究了结晶相和非晶相。通过扫描电子显微镜检查来检查地形特征，并使用能量色散X射线光谱分析法确定定量分析。在3,697和3,615 cm ^-1处观察到拉曼光谱的强OH拉伸分别用于TCmx和参考。但是，对于PCmx和PCpw，没有观察到OH模式。此外，TCmx和PCpw的指纹区域中的一些峰彼此重叠。在所有样品中均观察到硫酸钡和氢氧化钙的特征振动带，并且在样品的拉曼光谱中未观察到新的峰。人们发现基于氢氧化钙的药物在化学成分上有所不同。没有观察到新的结晶或非晶相峰。X射线粉末衍射分析仅匹配氢氧化钙和硫酸钡。X射线能谱分析表明，PCpw中的Ba和S元素含量低于TCmx和PCmx，而Cap中的Ca含量高于TCmx和PCmx。本研究揭示了不同形式的基于氢氧化钙的药物之间的结构差异。被测药物的媒介物和底物通过静电相互作用改变了化合物的物理化学性质。