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Ultrasonic-assisted efficient synthesis of inclusion complexes of salsalate drug and β-cyclodextrin derivatives for potent biomedical applications
Journal of Molecular Liquids ( IF 6 ) Pub Date : 2020-09-22 , DOI: 10.1016/j.molliq.2020.114358
Sonaimuthu Mohandoss , Thomas Nesakumar Jebakumar Immanuel Edison , Raji Atchudan , Subramanian Palanisamy , Narayanasamy Marimuthu Prabhu , Ayyakannu Arumugam Napoleon , SangGuan You , Yong Rok Lee

The inclusion complexes of the salsalate drug (SLT) with β-cyclodextrin derivatives (β-CDs); namely, β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HPβ-CD), and sulfobutylether-β-cyclodextrin (SBEβ-CD) are synthesized using the ultrasound process. The enhanced aqueous solubility of SLT is demonstrated by phase solubility diagram and optical spectroscopy, showing the inclusion complexation of β-CDs and SLT with a 1:1 stoichiometry. The β-CDs:SLT inclusion complexes exhibit potent bacterial activity against Staphylococcus aureus and Escherichia coli and reduce the cytotoxic effects of SLT on MCF-7 cells. The β-CDs:SLT complexes display further important activity for the inhibition of α-amylase and α-glucosidase, indicating their antidiabetic capability. The designed and synthesized inclusion complexes of SLT with β-CDs are widely expected to have potential applications in the preparation of novel pharmaceutical formulations containing SLT.



中文翻译:

超声辅助有效合成水杨酸盐药物和β-环糊精衍生物的包合物,用于有效的生物医学应用

盐酸盐药物(SLT)与β-环糊精衍生物(β-CDs)的包合物;即,使用超声波法合成β-环糊精(β-CD),羟丙基-β-环糊精(HPβ-CD)和磺丁基醚-β-环糊精(SBEβ-CD)。通过相溶解度图和光谱学证明了SLT的水溶性增强,显示了β-CD和SLT的化学计量比为1:1的包合物。β-CDs:SLT包合物对金黄色葡萄球菌大肠杆菌具有有效的细菌活性并降低SLT对MCF-7细胞的细胞毒性作用。β-CDs:SLT复合物在抑制α-淀粉酶和α-葡萄糖苷酶方面显示出更重要的活性,表明它们具有抗糖尿病的能力。人们广泛预期SLT与β-CDs的设计和合成包涵体复合物在制备含有SLT的新型药物制剂中具有潜在应用。

更新日期:2020-09-22
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