Reproductive outcomes associated with flame retardants among couples seeking fertility treatment: A paternal perspective,Environmental Research

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Reproductive outcomes associated with flame retardants among couples seeking fertility treatment: A paternal perspective
Environmental Research ( IF 8.3 ) Pub Date : 2020-09-22 , DOI: 10.1016/j.envres.2020.110226
Mary E Ingle ₁ , Lidia Mínguez-Alarcón ₂ , Courtney C Carignan ₃ , Heather M Stapleton ₄ , Paige L Williams ₅ , Jennifer B Ford ₂ , Molly B Moravek ₆ , Marie S O'Neill ₇ , Lu Wang ₈ , Russ Hauser ₉ , John D Meeker ₁ ,

Affiliation

Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Food Science and Nutrition, Michigan State University, East Lansing, MI, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Nicholas School of the Environment, Duke University, Durham, NC, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Michigan, Ann Arbor, MI, USA.
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background

Polybrominated diphenyl ethers (PBDEs) have been phased out of production for nearly a decade yet are still frequently detected in serum of U.S. adults. PBDE concentrations have been associated with adverse reproductive outcomes and laboratory studies suggest hydroxylated-BDEs (OH-BDEs) may act as endocrine disruptors. We set out to assess the joint effects of paternal and maternal serum PBDE concentrations on in vitro fertilization (IVF) outcomes and the association between paternal serum OH-BDE concentrations and IVF outcomes.

Methods

This analysis included 189 couples (contributing 285 IVF cycles) recruited between 2006 and 2016 from a longitudinal cohort based at Massachusetts General Hospital Fertility Center who completed at least one IVF cycle and had an available blood sample at study entry. Congeners (47, 99, 100, 153, and 154) and OH-BDEs (3-OH-BDE47, 5-OH-BDE47, 6-OH-BDE47 and 4-OH-BDE49) were quantified in serum. Log-transformed PBDEs and OH-BDEs were modeled in quartiles for associations with IVF outcomes using multivariable generalized mixed models and cluster weighted generalized estimating equations.

Results

Lipid-adjusted concentrations of PBDEs and OH-BDEs were higher in females than in male partners. There were no clear patterns of increases in risk of adverse IVF outcomes associated with PBDEs and OH-BDEs. However, some decreases in associations with IVF outcomes were observed in isolated quartiles.

Conclusions

Our assessment of couple level exposure is unique and highlights the importance of including male and female exposures in the assessment of the influence of environmental toxicants on pregnancy outcomes.

中文翻译：

寻求生育治疗的夫妇中与阻燃剂相关的生殖结果：父亲的观点

背景

多溴二苯醚 (PBDE) 已被淘汰近十年，但仍经常在美国成年人的血清中检测到。多溴二苯醚浓度与不利的生殖结果相关，实验室研究表明羟基化 BDEs (OH-BDEs) 可能充当内分泌干扰物。我们着手评估父亲和母亲血清 PBDE 浓度对体外受精(IVF) 结果的联合影响以及父亲血清 OH-BDE 浓度与 IVF 结果之间的关联。

方法

该分析包括在 2006 年至 2016 年期间从马萨诸塞州综合医院生育中心的纵向队列中招募的 189 对夫妇（贡献了 285 个 IVF 周期），他们至少完成了一个 IVF 周期并在研究开始时有可用的血液样本。对血清中的同源物（47、99、100、153 和 154）和 OH-BDE（3-OH-BDE47、5-OH-BDE47、6-OH-BDE47 和 4-OH-BDE49）进行了定量。使用多变量广义混合模型和聚类加权广义估计方程，对数转换的 PBDE 和 OH-BDE 以四分位数建模，用于与 IVF 结果的关联。