DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.

DNA携带着指导复杂生物过程的遗传信息。因此，维持稳定的基因组对于个体的生长发育和人类健康至关重要。DNA修复是修复受损DNA和恢复基因组稳定性的基本和保守机制，而其缺乏与多种人类疾病密切相关。近年来，在DNA修复和老化领域已取得了显着进展。在此，根据最新研究，我们将广泛讨论DNA损伤，DNA修复，衰老和衰老相关疾病之间的关系。此外，将讨论DNA修复在几种潜在的复兴策略中的可能作用。最后，我们还将回顾可能促进DNA修复未来研究的新兴方法。