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On the Famous Traditional Chinese Medicine "Fu Zi": Discovery, Research, and Development of Cardioactive Constituent Mesaconine.
Natural Products and Bioprospecting Pub Date : 2020-09-22 , DOI: 10.1007/s13659-020-00266-w
Feng-Peng Wang 1 , Ruo-Bing Chao 1
Affiliation  

Abstract

This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii (“Fu Zi”). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency, low toxicity, and a new mechanism.

Graphic Abstract



中文翻译:

关于著名的中药“傅子”:心脏活性成分美沙康宁的发现,研究和开发。

摘要

这篇综述总结了从虎头乌头(“子”)的侧根发现,研究和开发心脏活性成分美沙康宁的过程。迄今为止,临床前研究表明,美沙康宁是一种新型的强心药,具有相对较高的效力,较低的毒性和新的作用机制。

图形摘要

更新日期:2020-09-22
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