Two mixed-ligand coordination polymers with the chemical formulae {[Cu3(Hdpc)2(tib)2(H2O)2]·2H2O)}n (1, H3dpc = 2,6-di(4-carboxylphenyl)pyridine-4-carboxylic acid, tib = 1,3,5-tris(1-imidazolyl)benzene)) and [Cu(trans-chda)2(bimb)2·2H2O]n (2, H2chda = 1,4-cyclohexane(dicarboxylic)acid, bimb = 1,4-bis((1H-1,2,4-triazol-1-yl)methyl)benzene) are successfully prepared by the reaction of Cu(NO3)2·3H2O with different O-donor carboxylic acid and N-donor co-ligands under the solvothermal conditions. Furthermore, the treatment effect of the two compounds on the acute pancreatitis is evaluated in the biological experiment. Firstly, RT-PCR is performed to measure the relative expression level of the key genes of E. coli. Moreover, the inflammatory levels of the patients are evaluated by the ELISA detection of inflammatory cytokines, IL-1β, and TNF-α.

中文翻译：

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两种混合配体 Cu(II) 基配位聚合物：晶体结构和通过抑制细菌存活对儿童急性胰腺炎伴腹膜炎的治疗活性

化学式为 {[Cu3(Hdpc)2(tib)2(H2O)2]·2H2O)}n (1, H3dpc = 2,6-di(4-carboxylphenyl)pyridine-4-的两种混合配体配位聚合物羧酸，tib = 1,3,5-三(1-咪唑基)苯)) 和 [Cu(trans-chda)2(bimb)2·2H2O]n (2, H2chda = 1,4-环己烷(二羧酸)酸, bimb = 1,4-双((1H-1,2,4-三唑-1-基)甲基)苯)由Cu(NO3)2·3H2O与不同的O-供体羧酸反应成功制备和 N 供体共配体在溶剂热条件下。此外，在生物实验中评估了两种化合物对急性胰腺炎的治疗效果。首先进行RT-PCR检测大肠杆菌关键基因的相对表达水平。此外，通过ELISA检测炎症细胞因子、IL-1β和TNF-α来评估患者的炎症水平。