Russian Journal of Marine Biology ( IF 0.6 ) Pub Date : 2020-09-21 , DOI: 10.1134/s1063074020040057 N. F. Kushnerova , S. E. Fomenko , V. G. Sprygin , T. V. Momot
Abstract
The present study considers effects of a lipid complex isolated from the aqueous–ethanol (70%) extract from the marine red alga Ahnfeltia tobuchiensis and effects of the Essentiale commercial preparation on the biochemical parameters of blood plasma and erythrocyte membranes of mice exposed to experimental stress (suspension by the scruff of the neck). The pharmacological effect of the lipid complex from A. tobuchiensis is manifested as elimination of dyslipidemia and hypercholesterolemia accompanied by a reduction in the levels of total lipids and low-density lipoproteins, an increase in the level of high-density lipoproteins in plasma, and normalization of the cholesterol/phospholipid ratio and the phospholipid composition of erythrocyte membranes. The Ahnfeltia extract was not inferior to the Essentiale reference preparation in terms of effectiveness and was even superior in the potential to restore the blood lipid composition and the phospholipid fraction ratio in erythrocyte membranes. The pharmacological effect of the lipid complex from Ahnfeltia is determined by the action of its phospholipid fractions and polyunsaturated n-6 and n-3 fatty acids, which contribute to the utilization of cholesterol from membranes and the enhancement of the lipoprotein ratio towards increase in high-density lipoproteins and are also involved in erythrocyte membrane repair.
中文翻译:
海洋红藻提取物的脂类复合物在实验性应激暴露期间对血浆和红细胞膜生化参数的影响
摘要
本研究考虑了从海洋红藻Ahnfeltia tobuchiensis的乙醇水溶液(70%)提取物中分离的脂质复合物的作用,以及Essentiale商业制剂对暴露于实验应激的小鼠血浆和红细胞膜生化参数的影响(由颈背悬吊)。东武曲霉脂质复合物的药理作用表现为血脂异常和高胆固醇血症的消除,同时总脂质和低密度脂蛋白水平降低,血浆中高密度脂蛋白水平升高,并正常化胆固醇/磷脂比率和红细胞膜的磷脂组成。该Ahnfeltia提取物在功效上不逊于Essentiale参考制剂,甚至在恢复血脂成分和红细胞膜中磷脂比例方面的潜力甚至更高。Ahnfeltia脂质复合物的药理作用取决于其磷脂级分和多不饱和n-6和n-3脂肪酸的作用,这些脂肪酸有助于膜中胆固醇的利用和脂蛋白比例的增加,从而增加高胆固醇。密度脂蛋白,也参与红细胞膜修复。