Premature ovarian failure (POF) affects many adult women less than 40 years of age and leads to infertility. According to previous reports, various tissue-specific stem cells can restore ovarian function and folliculogenesis in mice with chemotherapy-induced POF. Human embryonic stem cells (ES) provide an alternative source for mesenchymal stem cells (MSCs) because of their similarities in phenotype and immunomodulatory and anti-inflammatory characteristics. Embryonic stem cell-derived mesenchymal stem cells (ES-MSCs) are attractive candidates for regenerative medicine because of their high proliferation and lack of barriers for harvesting tissue-specific MSCs. However, possible therapeutic effects and underlying mechanisms of transplanted ES-MSCs on cyclophosphamide and busulfan-induced mouse ovarian damage have not been evaluated.

中文翻译：

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人胚胎干细胞来源的间充质干细胞改善了卵巢早衰。

卵巢早衰（POF）影响许多不到40岁的成年女性，并导致不孕。根据以前的报道，各种组织特异性干细胞可以恢复化疗诱导的POF小鼠的卵巢功能和卵泡形成。人类胚胎干细胞（ES）由于其表型以及免疫调节和抗炎特性的相似性，为间充质干细胞（MSC）提供了另一种来源。胚胎干细胞来源的间充质干细胞（ES-MSC）是再生医学的诱人候选者，因为它们具有高增殖能力，并且没有收获组织特异性MSC的障碍。但是，尚未评估移植的ES-MSC对环磷酰胺和白消安引起的小鼠卵巢损伤的可能的治疗作用和潜在的机制。