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Effects of whey protein on glycemic control and serum lipoproteins in patients with metabolic syndrome and related conditions: a systematic review and meta-analysis of randomized controlled clinical trials.
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2020-09-21 , DOI: 10.1186/s12944-020-01384-7 Elaheh Amirani 1 , Alireza Milajerdi 2 , Željko Reiner 3, 4 , Hamed Mirzaei 1 , Mohammad Ali Mansournia 5 , Zatollah Asemi 1
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2020-09-21 , DOI: 10.1186/s12944-020-01384-7 Elaheh Amirani 1 , Alireza Milajerdi 2 , Željko Reiner 3, 4 , Hamed Mirzaei 1 , Mohammad Ali Mansournia 5 , Zatollah Asemi 1
Affiliation
This systematic review and meta-analysis aimed to assess the effects of whey protein on serum lipoproteins and glycemic status in patients with metabolic syndrome (MetS) and related disorders. Online databases, such as Web of Science, Cochrane Library, PubMed and Scopus were systematically searched by two independent authors from inception until 30th April 2020 for English randomized clinical trials investigating the efficacy of whey protein administration in subjects with Mets or related conditions on the parameters of glycemic and lipid control compared to certain control. In order to evaluate the included studies’ methodological quality, Cochrane Collaboration risk of bias tool was applied. Using Cochrane’s Q test and I-square (I2) statistic, the included trials’ heterogeneity was also examined. Using a random-effects model, data were pooled, and weighted mean difference (WMD) was considered as the overall effect size. Twenty-two studies were selected to be included in this meta-analysis. Consumption of whey protein resulted in significant reduction of HbA1c (WMD: -0.15; 95% CI: − 0.29, − 0.01) insulin (WMD: -0.94; 95% CI: − 1.68, − 0.21) and homeostasis model assessment-estimated insulin resistance (HOMA-IR) (WMD: -0.20; 95% CI: − 0.36, − 0.05). A significant reduction in triglycerides levels (WMD: -17.12; 95% CI: − 26.52, − 7.72), total cholesterol (WMD: -10.88; 95% CI -18.60, − 3.17), LDL-cholesterol levels (WMD: -8.47 95% CI: − 16.59, − 0.36) and total cholesterol/HDL-cholesterol ratio (WMD: -0.26; 95% CI: − 0.41, − 0.10) was found as well. This meta-analysis suggests that supplementation with whey protein had beneficial effect on several indicators of glycemic control and lipid parameters in patients with MetS and related conditions.
中文翻译：
乳清蛋白对代谢综合征和相关疾病患者的血糖控制和血清脂蛋白的影响：随机对照临床试验的系统评价和荟萃分析。
这项系统的综述和荟萃分析旨在评估乳清蛋白对代谢综合征（MetS）和相关疾病患者血清脂蛋白和血糖状态的影响。由两位独立作者从成立至2020年4月30日，系统地搜索了Web of Science，Cochrane图书馆，PubMed和Scopus等在线数据库，以进行英语随机临床试验，以研究在参数上符合Mets或相关条件的受试者中乳清蛋白给药的功效与某些对照相比，血糖和脂质的控制效果更好。为了评估纳入研究的方法学质量，使用了Cochrane协作偏倚风险工具。使用Cochrane的Q检验和I平方（I2）统计量，还检查了纳入试验的异质性。使用随机效应模型，对数据进行汇总，加权均数差（WMD）被视为整体效果大小。选择了22项研究纳入本荟萃分析。乳清蛋白的摄入导致HbA1c（WMD：-0.15; 95％CI：-0.29，-0.01）胰岛素（WMD：-0.94; 95％CI：-1.68，-0.21）显着降低，并且稳态模型评估了胰岛素电阻（HOMA-IR）（WMD：-0.20; 95％CI：-0.36，-0.05）。甘油三酸酯水平（WMD：-17.12; 95％CI：-26.52，-7.72），总胆固醇（WMD：-10.88; 95％CI -18.60，-3.17），LDL-胆固醇水平（WMD：-8.47）显着降低还发现95％CI：-16.59，-0.36）和总胆固醇/ HDL-胆固醇比（WMD：-0.26； 95％CI：-0.41，-0.10）。
更新日期：2020-09-21
中文翻译：
乳清蛋白对代谢综合征和相关疾病患者的血糖控制和血清脂蛋白的影响：随机对照临床试验的系统评价和荟萃分析。
这项系统的综述和荟萃分析旨在评估乳清蛋白对代谢综合征（MetS）和相关疾病患者血清脂蛋白和血糖状态的影响。由两位独立作者从成立至2020年4月30日，系统地搜索了Web of Science，Cochrane图书馆，PubMed和Scopus等在线数据库，以进行英语随机临床试验，以研究在参数上符合Mets或相关条件的受试者中乳清蛋白给药的功效与某些对照相比，血糖和脂质的控制效果更好。为了评估纳入研究的方法学质量，使用了Cochrane协作偏倚风险工具。使用Cochrane的Q检验和I平方（I2）统计量，还检查了纳入试验的异质性。使用随机效应模型，对数据进行汇总，加权均数差（WMD）被视为整体效果大小。选择了22项研究纳入本荟萃分析。乳清蛋白的摄入导致HbA1c（WMD：-0.15; 95％CI：-0.29，-0.01）胰岛素（WMD：-0.94; 95％CI：-1.68，-0.21）显着降低，并且稳态模型评估了胰岛素电阻（HOMA-IR）（WMD：-0.20; 95％CI：-0.36，-0.05）。甘油三酸酯水平（WMD：-17.12; 95％CI：-26.52，-7.72），总胆固醇（WMD：-10.88; 95％CI -18.60，-3.17），LDL-胆固醇水平（WMD：-8.47）显着降低还发现95％CI：-16.59，-0.36）和总胆固醇/ HDL-胆固醇比（WMD：-0.26； 95％CI：-0.41，-0.10）。
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