Music intervention has been applied to improve symptoms of schizophrenic subjects as a complementary treatment in medicine. Although the psychiatric symptoms, especially for motivation and emotion, could be increased in schizophrenia, the underlying neural mechanisms remain poorly understood. We employed a longitudinal study to measure the alteration of striatum functional networks in schizophrenic subjects undergoing Mozart music listening using resting-state functional magnetic resonance imaging (fMRI). Forty-five schizophrenic inpatients were recruited and randomly assigned to two groups. Under the standard care with antipsychotic medication, one group received music intervention for 1 month and the other group is set as control. Both schizophrenic groups were compared to healthy subjects. Resting-state fMRI was acquired from schizophrenic subjects at baseline and after one-month music intervention and from healthy subjects at baseline. Striatum network was assessed through seed-based static and dynamic functional connectivity (FC) analyses. After music intervention, increased static FC was observed between pallidum and ventral hippocampus in schizophrenic subjects. Increased dynamic FCs were also found between pallidus and subregions of default mode network (DMN), including cerebellum crus and posterior cingulate cortex. Moreover, static pallidus-hippocampus FC increment was positively correlated with the improvement of negative symptoms in schizophrenic subjects. Together, these findings provided evidence that music intervention might have an effect on the FC of the striatum-DMN circuit and might be related to the remission of symptoms of schizophrenia.

中文翻译：

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音乐干预对精神分裂症苍白球-DMN回路的影响

音乐干预已被用于改善精神分裂症患者的症状，作为医学上的补充治疗。尽管精神分裂症的精神症状，特别是动机和情感症状，可能会增加，但其潜在的神经机制仍知之甚少。我们进行了一项纵向研究，以测量使用静息态功能磁共振成像（fMRI）进行莫扎特音乐聆听的精神分裂症患者的纹状体功能网络的变化。招募四十五名精神分裂症住院患者，并将其随机分为两组。在使用抗精神病药物的标准护理下，一组接受音乐干预1个月，另一组作为对照组。将两个精神分裂症组与健康受试者进行比较。静止状态功能磁共振成像是在基线时和一个月音乐干预后从精神分裂症患者和基线时健康受试者获得的。纹状体网络通过基于种子的静态和动态功能连接（FC）分析进行评估。音乐干预后，在精神分裂症患者的苍白球与腹侧海马之间观察到静态FC增加。还发现苍白球和默认模式网络（DMN）的子区域之间的动态FC增加，包括小脑小结和后扣带回皮层。此外，精神分裂症患者的静态苍白球-海马FC增量与阴性症状的改善呈正相关。一起，