Abstract

The chemical investigation of the fruits of Xanthium strumarium (Asteraceae) led to the isolation of two new ent-kauranoid glucosides named 2-O-(6-O-isocaleryl-β-D-glucopyranosyl) atractyligenin (1) and 2-O-(2-O-isovaleryl-β-D-glucopyranosyl) atractyligenin (2), together with one known compound. Their structures were established by comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction and electronic circular dichroism data. All compounds and their aglycone were evaluated for their anti-proliferative activities in vitro against three human cancer cell lines.

摘要

Xanthium strumarium (Asteraceae)果实的化学研究导致分离出两种新的ent -kauranoid 苷，分别命名为 2- O -(6- O -isocaleryl- β -D-glucopyranosyl) atractyligenin ( 1 ) 和 2- O - (2 - O-异戊基-β -D-吡喃葡萄糖基)白术原素( 2 )，连同一种已知化合物。它们的结构是通过综合光谱分析结合单晶 X 射线衍射和电子圆二色性数据建立的。所有化合物及其苷元都在体外进行了抗增殖活性评估针对三种人类癌细胞系。