We applied combination antibiotic therapy to treat vertebral osteomyelitis and a psoas abscess caused by glycopeptide-intermediate (MIC, 2 μg/ml) and daptomycin-nonsusceptible (>2 μg/ml) methicillin-resistant Staphylococcus aureus. The Etest synergy test showed the largest synergistic effects for imipenem/cilastatin and fosfomycin. Whole-gene sequencing showed amino acid changes in SA0802, SA1193 (mprF), and SA1531 (ald). Four weeks of combination treatment using imipenem/cilastatin (1.5 g per day) and fosfomycin (4.0 g per day) resulted in clinical improvement.

中文翻译：

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亚胺培南加磷霉素作为椎骨骨髓炎的挽救疗法。

我们应用了联合抗生素疗法来治疗椎骨骨髓炎和糖肽中间体（MIC，2μg/ ml）和达托霉素敏感性（> 2μg/ ml）耐甲氧西林金黄色葡萄球菌引起的腰肌脓肿。Etest协同作用测试显示亚胺培南/西司他丁和磷霉素具有最大的协同作用。全基因测序显示SA0802，SA1193（mprF）和SA1531（ald）中的氨基酸变化。使用亚胺培南/西司他丁（每天1.5 g）和磷霉素（每天4.0 g）联合治疗的四个星期导致临床改善。