Benzazepines and benzodiazepines, benzofused seven‐membered N‐heterocycles, compose an important family of natural products and pharmaceuticals. Although certainly important and effectives, classical synthetic methods of these cyclic compounds involve methodologies that often require multistep procedures, with generation of waste materials and lack of sustainability. By contrast, cycloadditions based on transition metal catalyzed C−H bond activations (oxidative annulations) have emerged as appealing strategies for more sustainable synthetic processes. In this review, we focus our attention to describe the state‐of‐the‐art transition‐metal‐catalyzed annulations via C−H activations to benzazepines and benzodiazepines.

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过渡金属催化的苯并ze庚因和苯二氮卓类环化反应的最新进展

苯并稠合的七元N杂环苯并ze庚因和苯并二氮杂ose构成重要的天然产物和药物家族。尽管肯定重要且有效，但这些环状化合物的经典合成方法涉及的方法学通常需要多步操作，产生废料且缺乏可持续性。相比之下，基于过渡金属催化的CH键活化（氧化环化）的环加成反应已成为更具可持续性的合成工艺的诱人策略。在这篇综述中，我们将注意力集中在描述最先进的过渡金属催化的通过CH活化至苯并ze庚因和苯并二氮杂卓的环空上。