当前位置: X-MOL 学术ChemPhysChem › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Merging Gradient-Based Methods to Improve Benchtop NMR Spectroscopy: A New Tool for Flow Reaction Optimization.
ChemPhysChem ( IF 2.9 ) Pub Date : 2020-09-21 , DOI: 10.1002/cphc.202000573
Shrikant Kunjir 1 , Mireia Rodriguez-Zubiri 1 , Vincent Coeffard 1 , François-Xavier Felpin 1 , Patrick Giraudeau 1 , Jonathan Farjon 1
Affiliation  

Emerging low cost, compact NMR spectrometers that can be connected in‐line to a flow reactor are suited to study reaction mixtures. The main limitation of such spectrometers arises from their lower magnetic field inducing a reduced sensitivity and a weaker spectral resolution. For enhancing the spectral resolution, the merging of Pure‐Shift methods recognized for line narrowing with solvent elimination schemes was implemented in the context of mixtures containing protonated solvents. One more step was achieved to further enhance the resolution power on compact systems, thanks to multiple elimination schemes prior to Pure‐Shift pulse sequence elements. For the first time, we were able to remove up to 6 protonated solvent signals simultaneously by dividing their intensity by 500 to 1700 with a concomitant spectral resolution enhancement for signals of interest from 9 to 12 as compared to the standard 1D 1H. Then, the potential of this new approach was shown on the flow synthesis of a complex benzoxanthenone structure.

中文翻译:

合并基于梯度的方法以改善台式NMR光谱:流式反应优化的新工具。

可以串联连接到流动反应器的新兴低成本,紧凑型NMR光谱仪适用于研究反应混合物。这种光谱仪的主要局限性在于其较低的磁场,导致较低的灵敏度和较弱的光谱分辨率。为了提高光谱分辨率,在含有质子化溶剂的混合物中实施了将谱线变窄与溶剂消除方案相结合的Pure-Shift方法。由于在Pure-Shift脉冲序列元件之前采用了多种消除方案,因此可以进一步提高紧凑型系统的分辨率。首次,1 H.然后,这种新方法的电势显示在一个复杂的结构benzoxanthenone的流动合成。
更新日期:2020-10-19
down
wechat
bug