INTRODUCTION Health related quality of life (HRQoL) has become a pivotal outcome parameter after surgery for drug-resistant epilepsy. The aim of the study was to investigate HRQoL and its relationship to seizure outcome, neurological deficits and anxiety after epilepsy surgery in a specific subpopulation of elderly patients. METHODS A total of 85 elderly patients (older than 50 years) answered a standardized HRQoL questionnaire one year after epilepsy surgery. The questionnaire addressed the present self-assessed HRQoL in four subdomains (physical function, cognitive function, mood, social interaction). The questionnaire was based on the "Epilepsy Surgery Inventory-55", adapted for use in German speaking patients and validated by the QOLIE -10 and Beck Depression Inventory. RESULTS A total of 51 patients (60%) were completely seizure free (ILAE1) at last available outcome (LAO). Permanent neurological deficits were observed in 8 patients (7%). Correlation analysis confirmed significant association between seizure outcome and overall HRQoL (r = -0.368, p < .001). New permanent neurological deficits showed impact on both HRQoL and the "cognitive function" subdomain. Anxiety and subjective assessment of postoperative status were strongly correlated with overall HRQoL (r = 0.692, p < .001 and r = 0.591, p < .001 respectively) and remained as independent prognostic factors in a multivariate regression analysis. CONCLUSION Surgery for drug-resistant epilepsy in elderly improves patients' HRQoL. Both seizure freedom and new neurological deficits influence overall HRQoL. Interestingly, anxiety and patients' subjective assessment of postoperative status showed the highest impact on HRQoL in this subpopulation of epilepsy patients.

中文翻译：

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耐药性癫痫手术后老年患者的生活质量——癫痫发作结果、神经功能缺损和焦虑的影响

简介 与健康相关的生活质量 (HRQoL) 已成为耐药性癫痫手术后的关键结果参数。该研究的目的是在特定的老年患者亚群中研究 HRQoL 及其与癫痫手术后癫痫发作结果、神经功能缺损和焦虑的关系。方法 共有 85 名老年患者（50 岁以上）在癫痫手术一年后回答了标准化的 HRQoL 问卷。问卷在四个子领域（身体功能、认知功能、情绪、社交互动）解决了当前自我评估的 HRQoL。该问卷基于“癫痫手术量表-55”，适用于讲德语的患者，并通过 QOLIE -10 和贝克抑郁量表验证。结果 共有 51 名患者 (60%) 在最后可用的结果 (LAO) 中完全无癫痫发作 (ILAE1)。在 8 名患者 (7%) 中观察到永久性神经功能缺损。相关性分析证实癫痫发作结果与总体 HRQoL 之间存在显着关联（r = -0.368，p < .001）。新的永久性神经功能障碍对 HRQoL 和“认知功能”子域都有影响。术后状态的焦虑和主观评估与整体 HRQoL 密切相关（分别为 r = 0.692，p < .001 和 r = 0.591，p < .001），并且在多元回归分析中仍然是独立的预后因素。结论老年耐药性癫痫手术可提高患者的HRQoL。无癫痫发作和新的神经功能缺损都会影响整体 HRQoL。有趣的是，