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Impact of catch-up vaccination on aluminum exposure due to new laws and post social distancing
Journal of Trace Elements in Medicine and Biology ( IF 3.5 ) Pub Date : 2020-09-21 , DOI: 10.1016/j.jtemb.2020.126649
James Lyons-Weiler , Grant McFarland , Elaine La Joie

Background

The COVID-19 pandemic has placed significant stressors on the medical community and on the general public. Part of this includes patients skipping well-child visits to reduce risk of exposure to SARS-CoV-2 virus. Published estimates of the duration of whole-body aluminum (Al) toxicity from vaccines in infants from birth to six months indicate that CDC's recommended vaccination schedule leads to unacceptably long periods of time in which infants are in aluminum toxicity (as measured by %AlumTox).

Methods

We utilize these established clearance and accumulation models to calculate expected per-body-weight whole-body toxicity of aluminum from vaccines considering for children of all ages under CDC's Catch-Up schedule from birth to ten years, assuming social distancing for 6 months. Our updated Pediatric Dose Limit (PDL) model assumes a linear improvement in renal function from birth to two years.

Results

Our results indicate that due diligence in considering alternative spacing and use of non-aluminum containing vaccines when possible will reduce whole body toxicity and may reduce risk of morbidity associated with exposure to aluminum.

Conclusions

While reduction or elimination of aluminum exposure from all sources is always a good idea, our results indicate that careful consideration of expected aluminum exposures during regular and Catch-Up vaccination is found to be especially important for infants and children below 2 years of age. We urge caution in the mass re-starting of vaccination under CDC’s Catch-Up schedule for children under 12 months and offer alternative strategies to minimize per-day/week/month exposure to aluminum hydroxide following the COVID-19 period of isolation.



中文翻译:

由于新法规和社会隔离,补给疫苗接种对铝暴露的影响

背景

COVID-19大流行给医学界和公众带来了巨大压力。其中一部分包括患者跳过对孩子的拜访,以减少暴露于SARS-CoV-2病毒的风险。已公布的从出生到六个月的婴儿疫苗中全身铝(Al)毒性持续时间的公开估计表明,疾病预防控制中心(CDC)建议的疫苗接种时间表会导致婴儿出现铝中毒的时间过长(以%AlumTox衡量) 。

方法

我们使用这些已建立的清除率和累积模型,从CDC的赶超时间表(考虑到出生到十年)(假设社会距离为6个月)考虑所有年龄段的儿童,从疫苗计算铝的预期每人体重全身毒性。我们更新的小儿剂量限制(PDL)模型假设从出生到两年肾功能线性改善。

结果

我们的结果表明,尽职调查在可能的情况下考虑替代间隔和使用不含铝的疫苗将降低全身毒性,并可能降低与铝暴露相关的发病风险。

结论

虽然减少或消除所有来源的铝暴露始终是一个好主意,但我们的结果表明,发现常规和赶超疫苗接种过程中仔细考虑预期的铝暴露对于2岁以下的婴儿和儿童尤为重要。我们敦促在CDC的追赶时间表下针对12个月以下的儿童大规模重新开始疫苗接种,并建议采取其他策略来尽量减少隔离COVID-19之后每天/每周/每月的氢氧化铝暴露量。

更新日期:2020-09-25
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