OBJECTIVE To determine whether subfertility in patients with endometriosis is due to impaired endometrial receptivity by comparing pregnancy and live-birth outcomes in women with endometriosis versus two control groups without suspected endometrial factors: noninfertile patients who underwent assisted reproduction to test embryos for a single-gene disorder and couples with isolated male factor infertility. DESIGN Retrospective cohort. SETTING Multicenter private practice. PATIENT(S) All patients aged 24 to 44 years undergoing euploid frozen blastocysts transfer from January 2016 through March 2018. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Live birth, clinical pregnancies, pregnancy losses, and aneuploid rates in preimplantation genetic testing for aneuploidy cycles. RESULT(S) The analysis included 459 euploid frozen embryo transfer cycles among 328 unique patients. There were no differences in clinical pregnancy, pregnancy loss, or live-birth rates in patients with endometriosis compared with both control groups. The aneuploidy rates were lowest in the preimplantation genetic testing for monogenic disorders cohort, and the endometriosis patients had aneuploidy rates similar to those of the male factor infertility patients. CONCLUSION(S) It is unclear whether endometriosis primarily affects in vitro fertilization outcomes via oocyte quality or the endometrium. By controlling for embryo quality using euploid frozen embryo transfer cycles, we found no difference in pregnancy outcomes in patients with endometriosis compared with patients undergoing treatment for male factor infertility and noninfertile patients.

中文翻译：

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子宫内膜异位症不影响整倍体囊胚冷冻胚胎移植的活产率

目的 通过比较子宫内膜异位症女性的妊娠和活产结果与两个没有疑似子宫内膜因素的对照组（接受辅助生殖以检测单基因胚胎的非不育患者）的妊娠和活产结果，确定子宫内膜异位症患者的生育力低下是否是由于子宫内膜容受性受损所致障碍和夫妇与孤立的男性因素不育。设计回顾性队列。设置多中心私人诊所。患者 2016 年 1 月至 2018 年 3 月期间接受整倍体冷冻囊胚移植的所有 24 至 44 岁患者。 干预 无。主要结果测量活产、临床妊娠、流产和非整倍体周期的植入前基因检测中的非整倍体率。结果 分析包括 328 名独特患者中的 459 个整倍体冷冻胚胎移植周期。与两个对照组相比，子宫内膜异位症患者的临床妊娠、流产或活产率没有差异。在单基因疾病队列的胚胎植入前基因检测中，非整倍体率最低，子宫内膜异位症患者的非整倍体率与男性因素不育患者相似。结论（S）目前尚不清楚子宫内膜异位症是否主要通过卵母细胞质量或子宫内膜影响体外受精结果。通过使用整倍体冷冻胚胎移植周期控制胚胎质量，我们发现子宫内膜异位症患者与接受男性因素不孕症和非不育症患者治疗的患者相比，妊娠结局没有差异。