Aeolian dust can influence the climate, air quality, human health, and ecosystems. Dust events in Northern China are the main contributors to dust aerosols in the world, but the impacts of meteorological and anthropogenic factors and their interactions on dust events remain unclear. This study analyzed the spatial and temporal variations of dust event frequencies and quantitatively investigated the impacts of meteorological conditions, anthropogenic factors, and their interactions on dust events using the geographical detector model (GeoDetector) in Northern China. Results revealed that the dust event frequency significantly decreased by 0.006 times yr⁻¹ per site during 1980–2007. At the regional scale, there were large seasonal variations in the effects of meteorological conditions and anthropogenic factors on dust events. Strong winds and soil surface conditions are main drivers of dust events in spring. In summer and autumn, anthropogenic factors have significant impacts on the occurrence of dust events, but the frozen period and relative humidity are major impacting factors in winter. Effects of natural and anthropogenic factors on dust events showed great spatial and seasonal disparities over different vegetation regions. Interactions between two factors enhanced their impacts on the occurrence of dust events. There are also large spatial and seasonal variations in the primary interactions on dust events over different vegetation regions. The findings could help us to better understand the relative importance of various factors on dust events, which has important implications for improving the prediction of dust emission models and developing desertification control strategies.