Two new 2H-pyran-2-one glucosides, cuscutarosides A (1) and B (2), and one new steroidal glucoside, 7β-methoxy-β-sitosterol 3-O-β-glucopyranoside (3), together with 12 known compounds (4–15) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside (3) showed weak PPL inhibitory activity. Cuscutaroside A (1), its acetylated derivative (1a), and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA.

Graphic Abstract

中文翻译：

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弯角Cu全草的化学成分。

两个新的2 ħ -吡喃-2-酮葡糖苷，cuscutarosides A（1）和B（2），以及一个新的甾体糖苷，7 β甲氧基β谷甾醇3- ö - β吡喃葡萄糖苷（3），连同从弯角葫芦的整个植物中分离出12种已知化合物（4至15）。（旋花科）从缅甸收集。基于广泛的光谱分析，阐明了这些新化合物的化学结构。使用猪胰脂肪酶（PPL）评估这些分离株的抗肥胖活性，并使用凝血酶，血小板活化因子（PAF），花生四烯酸（AA）或胶原蛋白诱导的兔血小板筛选抗血小板聚集活性。7 β -甲氧基- β谷甾醇3- ö - β吡喃葡萄糖苷（3）显示出弱PPL抑制活性。s子苷A（1），其乙酰化衍生物（1a）和玄参苷B（8）显示出对胶原蛋白诱导的兔血小板聚集的弱抑制活性。化合物1a还显示出对由AA诱导的兔血小板聚集的抑制活性。

图形摘要