Data regarding mice exposed to Eastern, Venezuelan and Western equine encephalitis viruses (EEV, VEV and WEV respectively) were used to optimize two physiologically plausible dose response models. A rich data set was extracted from an intensive literature review, with 42 independent dose groups over three exposure routes: subcutaneous, intracranial and intraperitoneal. The data demonstrate the highly infectious nature of these encephalitis viruses to a general population. However, from an examination of the data, a dependency in the dose response relationship with respect to host age is likely. This host age dependency is manifesting as an increased resistance with increased host age, conversely, higher susceptibility at lower host ages. Considering the inability to pool host age groups under a nested model, this likely host age dependency is highlighted to a greater extent. Most of the host age groups (65%) could not be used for dose-response model optimization, leaving 13 host age groups of the original 37 that could be used for optimization. Those that could be used resulted in the exponential model being the better fitting model for 61% of those data, with the approximated form of the beta Poisson being the better fitting model for the remaining five data sets.

有关暴露于东部，委内瑞拉和西部马脑炎病毒（分别为EEV，VEV和WEV）的小鼠的数据用于优化两个生理上合理的剂量反应模型。从大量文献综述中提取了丰富的数据集，其中通过三种暴露途径（皮下，颅内和腹膜内）有42个独立剂量组。数据表明这些脑炎病毒对普通人群具有高度传染性。然而，从数据检查来看，剂量反应关系相对于宿主年龄可能是依赖的。这种寄主年龄依赖性表现为随着寄主年龄的增加，抵抗力增加，相反，在较低寄主年龄下的易感性较高。考虑到无法在嵌套模型下汇总托管年龄组，这种可能的宿主年龄依赖性在很大程度上得到了强调。大多数宿主年龄组（65％）不能用于剂量反应模型优化，而原来的37个宿主年龄组中有13个可以用于优化。可以使用的那些导致指数模型是这些数据中61％的最佳拟合模型，而贝叶斯泊松的近似形式是其余五个数据集的最佳拟合模型。