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Acute and chronic effects of resistance exercise training among young adults with and without analogue Generalized Anxiety Disorder: A protocol for pilot randomized controlled trials
Mental Health and Physical Activity ( IF 5.957 ) Pub Date : 2020-02-06 , DOI: 10.1016/j.mhpa.2020.100321
Brett R. Gordon , Cillian P. McDowell , Mark Lyons , Matthew P. Herring

Objectives

Recent meta-analyses support the chronic anxiolytic effects of resistance exercise training (RET) among women with diagnosed Generalized Anxiety Disorder (GAD). However, the effects of RET among those with subclinical, or analogue, GAD (AGAD) is unknown. The purpose of the pilot randomized controlled trial (RCT) detailed in this protocol was to quantify the acute and chronic effects of RET on signs and symptoms of GAD among young adults with and without AGAD.

Methods

This protocol details the full methods of two parallel, RCTs of an eight-week RET intervention compared to a wait-list control condition among young adults with and without AGAD. AGAD status was determined using validated cut-scores for both the Psychiatric Diagnostic Screening Questionnaire GAD subscale (≥6) and the Penn State Worry Questionnaire (≥45). The ecologically-valid RET was designed according to World Health Organization and American College of Sports Medicine guidelines. The primary outcome was AGAD status, assessed pre- and post-intervention. Secondary outcomes were assessed weekly. Two acute RET trials were nested within the design at pre- and post-intervention to determine response and change in response to a single bout of RET.

Conclusions

This pilot RCT examines the effect of an ecologically-valid RET intervention among young adults with subclinical levels of GAD. Given that GAD most often emerges during young adulthood, and young adults who display elevated subclinical symptoms are more likely to develop clinically significant psychopathology, investigating the effects of RET among individuals with emerging signs and symptoms of an anxiety disorder is particularly important.

Trial registration

ClinicalTrials.gov Identifier: NCT04116944.



中文翻译:

有和没有类似的全身性焦虑症的青壮年抵抗运动训练的急性和慢性影响:一项随机试验的协议

目标

最近的荟萃分析支持了被诊断为广泛性焦虑症(GAD)的女性的抵抗运动训练(RET)的慢性抗焦虑作用。但是,在亚临床或类似的GAD(AGAD)患者中,RET的作用尚不清楚。该协议中详细介绍的中试随机对照试验(RCT)的目的是量化RET对患有和不患有AGAD的年轻成年人中GAD体征和症状的急性和慢性影响。

方法

该协议详细介绍了八周RET干预的两个并行RCT的完整方法,与患有和不患有AGAD的青壮年相比,其等待名单控制情况。使用精神病学诊断筛查问卷GAD子量表(≥6)和宾夕法尼亚州忧虑问卷(≥45)的有效切分来确定AGAD状态。生态有效的RET是根据世界卫生组织和美国运动医学学院的指南设计的。主要结果是AGAD状态,在干预前后进行评估。每周评估次要结局。干预前后,在设计中嵌套了两项急性RET试验,以确定对单次RET的反应和反应。

结论

这项RCT试点研究了亚临床GAD水平的年轻人对生态有效的RET干预的效果。鉴于GAD最常见于成年期,而表现出亚临床症状升高的青壮年更有可能发展出具有临床意义的心理病理学,因此调查RET对新出现焦虑症和体征的个体的影响尤为重要。

试用注册

ClinicalTrials.gov标识符:NCT04116944。

更新日期:2020-02-06
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