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Three-dimensional imaging of spatio-temporal dynamics of small blood capillary network in the cortex based on optical coherence tomography: A review
Journal of Innovative Optical Health Sciences ( IF 2.5 ) Pub Date : 2019-11-12 , DOI: 10.1142/s1793545820300025
Fangjian Xing 1, 2 , Jang-Hoon Lee 2 , Collin Polucha 2 , Jonghwan Lee 2, 3
Affiliation  

Optical coherence tomography angiography (OCTA) has emerged as an advanced in vivo imaging modality, which is widely used for the clinic ophthalmology and neuroscience research in the rodent brain cortex among others. Based on the high numerical aperture (NA) probing lens and the motion-corrected algorithms, a high-resolution imaging technique called OCT micro-angiography is applied to resolve the small blood capillary vessels ranging from 5[Formula: see text][Formula: see text]m to 10[Formula: see text][Formula: see text]m in diameter. As OCT-based techniques are recently evolving further from the structural imaging of capillaries toward spatio-temporal dynamic imaging of blood flow in capillaries, here we present a review on the latest techniques for the dynamic flow imaging. Studies on capillary blood flow using these techniques will help us better understand the roles of capillary blood flow for normal functioning of the brain as well as how it malfunctions in diseases.

中文翻译:

基于光学相干断层扫描的皮层小毛细血管网络时空动态三维成像:综述

光学相干断层扫描血管造影(OCTA)已成为一种先进的体内成像方式,广泛用于啮齿动物大脑皮层的临床眼科和神经科学研究。基于高数值孔径(NA)探测透镜和运动校正算法,应用一种称为OCT微血管造影的高分辨率成像技术来分辨5 [公式:见正文] [公式:见正文]m 至 10[公式:见正文][公式:见正文]直径。随着基于 OCT 的技术最近从毛细血管的结构成像向毛细血管血流的时空动态成像进一步发展,我们在此回顾了动态血流成像的最新技术。
更新日期:2019-11-12
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