Histopathological examination is still the gold standard for diagnoses of oral-maxillofacial lesions, but it is invasive and time-consuming. Optical coherence tomography (OCT) provides a kind of noninvasive, label-free, real-time and high-resolution imaging technology. In this study, in order to assess the feasibility of OCT in oral clinical application, fresh excised tissue specimens from 59 patients undergoing oral-maxillofacial surgery were imaged in detail by using a benchtop swept-source OCT system. It is shown that different lesions or tissues can be obviously distinguished based on their different microstructural features in OCT images, and the features are similar to those of their corresponding histopathological images. It is proven that OCT has great feasibility and potential as a diagnostic aid for surgeons in oral medicine.

中文翻译：

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使用光学相干断层扫描对口腔颌面部病变进行术中成像

组织病理学检查仍然是诊断口腔颌面部病变的金标准，但它具有侵入性且耗时。光学相干断层扫描（OCT）提供了一种无创、无标记、实时和高分辨率的成像技术。在这项研究中，为了评估 OCT 在口腔临床应用中的可行性，使用台式扫描源 OCT 系统对来自 59 名接受口腔颌面外科手术的患者的新鲜切除组织标本进行详细成像。结果表明，根据OCT图像中不同的显微结构特征，可以明显区分不同的病变或组织，且特征与其对应的组织病理学图像相似。事实证明，OCT 作为口腔医学外科医生的诊断辅助工具具有很大的可行性和潜力。