The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matrix (ECM) components involved in the regulation of stem cell fate (self-renewal, survival, and differentiation into more mature phenotypes like hepatocytes and cholangiocytes). In this review, we describe and summarize all the major components that play essential roles in the liver stem cell niche, in particular, growth factor signaling and the biomechanical properties of the ECM.

肝干细胞生态位是一个专门的动态微环境，具有调节干细胞行为的生物力学和生化特征。由于涉及分泌因子，小分子，神经，血液输入和细胞外基质（ECM）成分的复杂网络的协调，这是可行的，其中涉及干细胞命运的调节（自我更新，存活和分化成更成熟的表型）例如肝细胞和胆管细胞）。在这篇综述中，我们描述和总结了在肝干细胞生态位中起重要作用的所有主要成分，特别是生长因子信号传导和ECM的生物力学特性。