A regioselective rhodium-catalyzed carboxylate-directed thiolation process was developed. Several benzoic-acid derivatives and disulfides were found to be well-tolerated, and they yielded the corresponding products in moderate to good yields. Compounds such as the key precursor of roflumilast can be obtained via this reaction, thereby highlighting the potential of this synthetic approach.

中文翻译：

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铑（III）催化的羧酸定向的苯甲酸邻位选择性硫醇化

开发了区域选择性铑催化的羧酸盐定向的硫醇化方法。发现几种苯甲酸衍生物和二硫化物具有良好的耐受性，它们以中等至良好的产率产生了相应的产物。可以通过该反应获得诸如罗氟司特的关键前体的化合物，从而突出了这种合成方法的潜力。