Scorpion venom is a very complicated mixture of various peptides/proteins which could induce toxicological and pharmacological responses. This investigation was conducted to evaluate the possible pharmacological properties (analgesic, antipyretic, and antiinflammatory effects) of the Egyptian scorpion venom Androctonus amoreuxi in mice and rats injected intraperitoneally with 1/10 and 1/5 LD50 (0.11 and 0.22 mg/kg for mice; 0.385 and 0.77 mg/kg for rats, respectively). The peripheral and central analgesic effect of A. amoreuxi venom was determined using the tests of mice-abdominal writhing and tail immersion of rats, respectively. The antipyretic and antiinflammatory activities were examined using the pyrexia rats model induced by Brewer’s yeast and the paw mice edema induced by carrageenan, respectively. The venom of A. amoreuxi produced significant (p < 0.05) peripheral and central analgesic activity in both animal models. Also, treatment with the scorpion venom showed significant (p < 0.05) dose-independent reduction in pyrexia of rats. More importantly, the venom significantly inhibited mice paw edema induced by carrageenan. Accordingly, the present results showed that the venom of this scorpion possesses remarkable pharmacological properties (analgesic, antipyretic, and antiinflammatory activities) on animal models, and might be contain certain peptides responsible for the reported activities.

中文翻译：

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埃及蝎 Androctonus amoreuxi 毒液诱导的镇痛、抗炎和解热作用

蝎毒是各种肽/蛋白质的非常复杂的混合物，可引起毒理学和药理学反应。本研究旨在评估埃及蝎毒 Androctonus amoreuxi 对小鼠和大鼠腹腔注射 1/10 和 1/5 LD50（小鼠 0.11 和 0.22 mg/kg）的可能药理特性（镇痛、解热和抗炎作用） ；大鼠分别为 0.385 和 0.77 mg/kg）。Amoreuxi毒液的外周和中枢镇痛作用分别通过小鼠腹部扭体试验和大鼠尾浸试验确定。分别使用啤酒酵母诱导的发热大鼠模型和角叉菜胶诱导的爪鼠水肿检测解热和抗炎活性。A的毒液 amoreuxi 在两种动物模型中产生显着的 (p < 0.05) 外周和中枢镇痛活性。此外，蝎毒治疗显示大鼠发热显着（p < 0.05）剂量依赖性降低。更重要的是，毒液显着抑制了角叉菜胶引起的小鼠爪水肿。因此，目前的结果表明，这种蝎子的毒液在动物模型上具有显着的药理特性（镇痛、解热和抗炎活性），并且可能含有与报道活性有关的某些肽。该毒液显着抑制角叉菜胶引起的小鼠爪水肿。因此，目前的结果表明，这种蝎子的毒液在动物模型上具有显着的药理特性（镇痛、解热和抗炎活性），并且可能含有与报道活性有关的某些肽。该毒液显着抑制角叉菜胶引起的小鼠爪水肿。因此，目前的结果表明，这种蝎子的毒液在动物模型上具有显着的药理特性（镇痛、解热和抗炎活性），并且可能含有与报道活性有关的某些肽。