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Evaluation of cerebrospinal fluid flow dynamic changes in patients with idiopathic intracranial hypertension using phase contrast cine MR imaging
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Pub Date : 2020-09-18 , DOI: 10.1186/s41983-020-00227-7
Tamer Belal , Abd-Elhalim Al Tantawy , Fatema Mohamed Sherif , Alshaimaa Ramadan

Background Idiopathic intracranial hypertension (IIH) mainly affects overweight women in the middle age period. The pathophysiology of IIH stays unclear, but suggested mechanisms include excess CSF production, reduced CSF absorption, increased brain water content, and increased cerebral venous pressure Objectives To assess the cerebrospinal fluid (CSF) flow dynamic changes in aqueduct of Sylvius in patients of idiopathic intracranial hypertension (IIH) with new MRI technique: phase contrast cine MRI (PCC-MRI). Methods Thirty patients diagnosed with idiopathic intracranial hypertension were divided into 3 groups according to treatment options (no treatment, medical treatment, and medical treatment with repeated lumbar tapping). CSF flow data were evaluated by phase contrast cine MRI. Results PCC-MRI parameters were significantly higher in group who was on medical treatment (group II) than other groups. The sensitivity of PCC MRI parameters ranged from 56.7 (stroke volume (SV) and mean flow (MF)) to 83.3% (peak systolic velocity (PSV)). A statistically significant difference was found for the mean flow value ( p 0.039) between the control group and IIH patients. Conclusion The most specific CSF flowmetry parameter detected to help diagnosis of IIH is mean flow especially among early discovered patients. PCC MRI can be used as non-invasive technique for diagnosis of IIH and treatment follow-up.

中文翻译:

相衬电影磁共振成像评估特发性颅内高压患者脑脊液流动动态变化

背景 特发性颅内高压 (IIH) 主要影响中年超重女性。IIH 的病理生理学尚不清楚,但建议的机制包括脑脊液产生过多、脑脊液吸收减少、脑含水量增加和脑静脉压升高高血压 (IIH) 与新的 MRI 技术:相衬电影 MRI (PCC-MRI)。方法将30例确诊为特发性颅内高压的患者按治疗方案(不治疗、药物治疗、内科反复叩诊)分为3组。通过相差电影 MRI 评估脑脊液流量数据。结果内科治疗组(Ⅱ组)PCC-MRI参数明显高于其他组。PCC MRI 参数的灵敏度范围从 56.7(每搏输出量 (SV) 和平均流量 (MF))到 83.3%(峰值收缩速度 (PSV))。发现对照组和 IIH 患者之间的平均流量值 (p = 0.039) 存在统计学显着差异。结论 检测到的有助于诊断 IIH 的最具体的 CSF 流量测量参数是平均流量,尤其是在早期发现的患者中。PCC MRI 可用作诊断 IIH 和治疗随访的非侵入性技术。发现对照组和 IIH 患者之间的平均流量值 (p = 0.039) 存在统计学显着差异。结论 检测到的有助于诊断 IIH 的最具体的 CSF 流量测量参数是平均流量,尤其是在早期发现的患者中。PCC MRI 可用作诊断 IIH 和治疗随访的非侵入性技术。发现对照组和 IIH 患者之间的平均流量值 (p = 0.039) 存在统计学显着差异。结论 检测到的有助于诊断 IIH 的最具体的 CSF 流量测量参数是平均流量,尤其是在早期发现的患者中。PCC MRI 可用作诊断 IIH 和治疗随访的非侵入性技术。
更新日期:2020-09-18
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