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NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model.
Particle and Fibre Toxicology ( IF 10 ) Pub Date : 2020-09-18 , DOI: 10.1186/s12989-020-00368-w
Falko Frenzel 1 , Laura König-Mattern 2 , Valerie Stock 1 , Linn Voss 1 , Maxi B Paul 1 , Holger Sieg 1 , Albert Braeuning 1 , Andreas Voigt 2 , Linda Böhmert 1
Affiliation  

Nanoparticles exhibit a specific diffusion and sedimentation behavior under cell culture conditions as used in nantoxicological in vitro testing. How a particular particle suspension behaves depends on the particular physicochemical characteristics of the particles and the cell culture system. Only a fraction of the nanoparticles applied to a cell culture will thus reach the cells within a given time frame. Therefore, dosimetric calculations are essential not only to determine the exact fraction of nanoparticles that has come into contact with the cells, but also to ensure experimental comparability and correct interpretation of results, respectively. Yet, the use of published dosimetry models is limited. Not the least because the correct application of these in silico tools usually requires bioinformatics knowledge, which often is perceived a hurdle. Moreover, not all models are freely available and accessible. In order to overcome this obstacle, we have now developed an easy-to-use interface for our recently published 3DSDD dosimetry model, called NanoPASS (NanoParticle Administration Sedimentation Simulator). The interface is freely available to all researchers. It will facilitate the use of in silico dosimetry in nanotoxicology and thus improve interpretation and comparability of in vitro results in the field.

中文翻译:

NanoPASS:使用3DSDD模型进行纳米颗粒剂量测定的易于使用的用户界面。

纳米颗粒在细胞培养条件下表现出特定的扩散和沉降行为,如纳米毒理学体外测试中所使用。特定的颗粒悬浮液的行为方式取决于颗粒和细胞培养系统的特定物理化学特性。因此,仅一小部分应用于细胞培养的纳米颗粒将在给定的时间范围内到达细胞。因此,剂量学计算不仅对于确定已与细胞接触的纳米颗粒的确切比例至关重要,而且对于分别确保实验可比性和正确解释结果也至关重要。但是,已公开的剂量学模型的使用受到限制。尤其重要的是,正确使用这些计算机工具通常需要生物信息学知识,通常被认为是一个障碍。此外,并非所有模型都可以免费获得和访问。为了克服这一障碍,我们现在为最近发布的3DSDD剂量测定模型开发了一个易于使用的界面,称为NanoPASS(NanoParticle管理沉淀模拟器)。该界面可供所有研究人员免费使用。这将有助于在纳米毒理学中使用计算机模拟剂量法,从而提高该领域体外结果的解释性和可比性。
更新日期:2020-09-20
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