The ligands of (E)-bis(p-3-nitrobenzoic acid) vinyl (C16H10N2O8) were synthesized in three steps, and then the MOF-Zn2(EBNB)2(BPY)2·2H2O was synthesized by solvothermal method. This structure was characterized by X-ray single crystal diffraction, SEM and TG. The drug loading and in vitro release of Zn2(EBNB)2(BPY)2·2H2O were also studied with Methadone as model drug. The results show that the highest loading amount of Zn2(EBNB)2(BPY)2·2H2O to Methadone was 0.256 g/g, and the drug delivery system was a two-phase mode. The results of in vitro cytotoxicity test show that Zn2(EBNB)2(BPY)2·2H2O has good biocompatibility.

中文翻译：

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MOF-Zn2（EBNB）2（BPY）2·2H2O的性质及其负载美沙酮的基础研究。

通过三个步骤合成（E）-双（对-3-硝基苯甲酸）乙烯基（C16H10N2O8）的配体，然后通过溶剂热法合成MOF-Zn2（EBNB）2（BPY）2·2H2O。通过X射线单晶衍射，SEM和TG来表征该结构。以美沙酮为模型药物，研究了Zn2（EBNB）2（BPY）2·2H2O的载药量和体外释放。结果表明，美沙酮对Zn2（EBNB）2（BPY）2·2H2O的最高负载量为0.256 g / g，药物输送系统为两相模式。体外细胞毒性试验结果表明，Zn2（EBNB）2（BPY）2·2H2O具有良好的生物相容性。