The rapid emergence of air-mediated diseases in a micro-climate demands on-site monitoring of airborne microparticles. The on-site detection of airborne microparticles becomes more challenging as the particles are highly localized and change dynamically over time. However, most existing monitoring systems rely on time-consuming sample collection and centralized off-site analysis. Here, we report a smartphone-based integrated microsystem for on-site collection and detection that enables real-time detection of indoor airborne microparticles with high sensitivity. The collection device, inspired by the Venturi effect, was designed to collect airborne microparticles without requiring an additional power supply. Our systematic analysis showed that the collection device was able to collect microparticles with consistent negative pressure, regardless of the particle concentration in the air sample. By incorporating a microfluidic-biochip based on inertial force to trap particles and an optoelectronic photodetector into a miniaturized device with a smartphone, we demonstrate real-time and sensitive detection of the collected airborne microparticles, such as Escherichia coli, Bacillus subtilis, Micrococcus luteus, and Staphylococcus with a particle-density dynamic range of 10³–10⁸ CFU mL⁻¹. Because of its capabilities of minimal-power sample collection, high sensitivity, and rapid detection of airborne microparticles, this integrated platform can be readily adopted by the government and industrial sectors to monitor indoor air contamination and improve human healthcare.

中文翻译：

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集成的现场采集和检测空气中的微粒，用于基于智能手机的微气候质量控制。

在微气候中空气介导疾病的迅速出现要求对空气中的微粒进行现场监测。空气中微粒的现场检测变得更具挑战性，因为微粒高度定位并随时间动态变化。但是，大多数现有的监视系统都依赖耗时的样本收集和集中的异地分析。在这里，我们报告了一个基于智能手机的集成微系统，用于现场收集和检测，该系统能够以高灵敏度实时检测室内机载微粒。受文丘里效应的启发，该收集装置设计用于收集空气中的微粒，而无需额外的电源。我们的系统分析表明，该收集装置能够收集负压恒定的微粒，无论空气样品中的颗粒浓度如何。通过将基于惯性力的微流体生物芯片与智能手机集成到微型设备中，以捕获颗粒和光电光电探测器，我们演示了对收集的空气中微粒的实时和灵敏检测，例如大肠杆菌，枯草芽孢杆菌，黄球微球菌和葡萄球菌的颗粒密度动态范围为10 ³ –10 ⁸ CFU mL ^-1。由于其具有最小功耗的样品采集功能，高灵敏度以及对空气中微粒的快速检测功能，该集成平台可以为政府和工业部门所采用，以监控室内空气污染并改善人类医疗保健。