Tandem [5 + 2]/[4 + 2] Cycloadditions To Construct the [6-7-6] Tricyclic Skeleton of Icetexane Diterpenes: Total Synthesis of Euolutchuol E, Przewalskine E and Brussonol.,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Tandem [5 + 2]/[4 + 2] Cycloadditions To Construct the [6-7-6] Tricyclic Skeleton of Icetexane Diterpenes: Total Synthesis of Euolutchuol E, Przewalskine E and Brussonol.
Organic Letters ( IF 5.2 ) Pub Date : 2020-09-18 , DOI: 10.1021/acs.orglett.0c02309
Jing Zhang _{1,

2} , Yehua Jin ₃ , Fayang G Qiu _{1,

3}

Affiliation

The collective total synthesis of the icetexane diterpenoids euolutchuol E, przewalskine E, and brussonol is described. An efficient synthetic strategy features two key transformations: (a) a tandem [5 + 2]/[4 + 2] cycloaddition reaction strategy to efficiently build the full-carbon skeleton of the icetexane diterpenoids; (b) an efficient aromatization of the C-ring of the icetexane diterpenoids using SeO₂.

中文翻译：

串联[5 + 2] / [4 + 2]环加成反应以构建[6-7-6] Icetexane二萜的三环骨架：Euolutchuol E，Przewalskine E和Brussonol的全合成。

描述了冰tex烷二萜类化合物Euolutchuol E，普泽瓦尔西汀E和布鲁索醇的总合成。一种有效的合成策略具有两个关键的转变：（a）串联[5 + 2] / [4 + 2]环加成反应策略，以有效地构建冰tex烷二萜的全碳骨架；（b）使用SeO ₂有效地使冰烷二萜类化合物的C环芳构化。

更新日期：2020-10-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>