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Pd-Catalyzed C(sp3)-H Biarylation via Transient Directing Group Strategy.
Organic Letters ( IF 5.2 ) Pub Date : 2020-09-18 , DOI: 10.1021/acs.orglett.0c02353
Mingruo Ding , Wenkai Hua , Min Liu , Fengzhi Zhang 1
Affiliation  

Here, we describe a highly selective Pd-catalyzed C(sp3)–H biarylation of 2-methylbenzaldehydes using cyclic diaryliodonium salts as arylation reagents. The key strategy is the employment of tert-leucine as a bidentate transient directing group for the proximity-driven metalation to achieve reactivity and selectivity in C–H activation. Various functionalized biaryls bearing both aldehyde and iodine functional groups were prepared successfully, which could be further transformed into a wide range of compounds with potential applications in pharmaceutical chemistry and materials science.

中文翻译:

钯催化的C(sp3)-H二元化通过瞬态指导组策略。

在这里,我们描述了使用环二芳基碘鎓盐作为芳基化试剂的2-甲基苯甲醛的高选择性Pd催化C(sp 3)-H双芳基化。关键策略是采用亮氨酸作为邻近驱动金属化的二齿过渡指导基团,以实现CH活化中的反应性和选择性。成功地制备了同时带有醛和碘官能团的各种官能化联芳基,它们可以进一步转化为多种化合物,在药物化学和材料科学中具有潜在的应用前景。
更新日期:2020-10-02
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