Based on high-resolution tandem mass spectrometry (HR-MS²) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.

中文翻译：

---

白蚁相关的 Actinomadura sp. 对异黄酮类化合物的多卤化作用。RB99。

基于高分辨率串联质谱 (HR-MS ² ) 和全球天然产物社交分子网络 (GNPS)，我们发现植物来源的黄豆苷元和染料木黄酮衍生物被与白蚁相关的Actinomadura物种 RB99多卤化。从优化条件下生长的细菌提取物的 MS 引导纯化导致分离出八种多氯异黄酮，包括六种未报告的衍生物和七种新型多溴化衍生物，其中两种具有抗菌活性。