Gold nanorods exhibit a wide variety of applications such as tumor molecular imaging and photothermal therapy (PTT) due to their tunable optical properties. Several studies have demonstrated that the combination of other therapeutic strategies may improve PTT efficiency. A method called optical droplet vaporization (ODV) was considered as another noninvasive imaging and therapy strategy. Via the ODV method, superheated perfluorocarbon droplets can be vaporized to a gas phase for enhancing ultrasound imaging; meanwhile, this violent process can cause damage to cells and tissue. In addition, active targeting through the functionalization with targeting ligands can effectively increase nanoprobe accumulation in the tumor area, improving the sensitivity and specificity of imaging and therapy. Our study prepared a nanoparticle loaded with gold nanorods and perfluorinated hexane and conjugated to a monoclonal antibody (MAGE-1 antibody) to melanoma-associated antigens (MAGE) targeting melanoma, investigated the synergistic effect of PTT/ODV therapy, and monitored the therapeutic effect using ultrasound. The prepared MAGE-Au-PFH-NPs achieved complete eradication of tumors. Meanwhile, the MAGE-Au-PFH-NPs also possess significant ultrasound imaging signal enhancement, which shows the potential for imaging-guided tumor therapy in the future.

中文翻译：

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针对黑素瘤的超声成像引导光疗的靶向MAGE的金纳米颗粒。

金纳米棒由于具有可调的光学特性，因此具有广泛的应用，例如肿瘤分子成像和光热疗法（PTT）。几项研究表明，其他治疗策略的组合可以提高PTT的效率。一种称为光滴汽化（ODV）的方法被认为是另一种非侵入性成像和治疗策略。通过ODV方法，可以将过热的全氟化碳液滴蒸发成气相以增强超声成像；同时，这种暴力过程可能会损坏细胞和组织。另外，通过靶向配体的功能化进行的主动靶向可以有效地增加纳米探针在肿瘤区域的积累，从而提高成像和治疗的敏感性和特异性。我们的研究制备了负载有金纳米棒和全氟化己烷并与针对黑色素瘤的黑色素瘤相关抗原（MAGE）的单克隆抗体（MAGE-1抗体）偶联的纳米颗粒，研究了PTT / ODV治疗的协同效应，并监测了治疗效果使用超声波。制备的MAGE-Au-PFH-NPs可以完全根除肿瘤。同时，MAGE-Au-PFH-NPs还具有显着的超声成像信号增强功能，这显示了将来在成像指导的肿瘤治疗中的潜力。制备的MAGE-Au-PFH-NPs可以完全根除肿瘤。同时，MAGE-Au-PFH-NPs还具有显着的超声成像信号增强功能，这显示了将来在成像指导的肿瘤治疗中的潜力。制备的MAGE-Au-PFH-NPs可以完全根除肿瘤。同时，MAGE-Au-PFH-NPs还具有显着的超声成像信号增强功能，这显示了将来在成像指导的肿瘤治疗中的潜力。