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Correction to High F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging.
ACS Nano ( IF 17.1 ) Pub Date : 2020-09-18 , DOI: 10.1021/acsnano.0c07373
Cheng Zhang , Shehzahdi Shebbrin Moonshi , Wenqian Wang , Hang Thu Ta , Yanxiao Han , Felicity Y. Han , Hui Peng , Petr Král , Barbara E. Rolfe , J. Justin Gooding , Katharina Gaus , Andrew K. Whittaker

The incorrect image of the histology section was used for Figure 6E (HBPFPE-non of the spleen) in the original manuscript. The correct image has now been included and confirms again that there were no apparent histopathologic changes in all tissues examined, including the spleen. Figure 6. Ex vivo fluorescence, 19F NMR, and histological analysis. (A) Co-registered X-ray and fluorescence images and (B) quantified biodistribution data collected ex vivo of harvested mice organs 48 h PI of PBS, HBPFPE-non and HBPFPE-apt. The plots are of the mean ± SD (n = 4 mice/group). (C) Intratumoral 19F NMR spectra and (D) 19F NMR T1 and T2 relaxation curves and times of polymer within the tumor 48 h after injection. The temperature was set to 37 °C during NMR acquisition. The relaxation times of the HBPFPE nanoparticles at a field strength of 9.4 T were measured for the peak F1. (E) Histological sections in the acute toxicity test (H&E staining, 40×). The scale bar represents 20 μm. There are no apparent histopathologic changes observed in the tissues, including lung, heart, liver, kidney, and spleen for both HBPFPE-non and HBPFPE-apt. This article has not yet been cited by other publications. Figure 6. Ex vivo fluorescence, 19F NMR, and histological analysis. (A) Co-registered X-ray and fluorescence images and (B) quantified biodistribution data collected ex vivo of harvested mice organs 48 h PI of PBS, HBPFPE-non and HBPFPE-apt. The plots are of the mean ± SD (n = 4 mice/group). (C) Intratumoral 19F NMR spectra and (D) 19F NMR T1 and T2 relaxation curves and times of polymer within the tumor 48 h after injection. The temperature was set to 37 °C during NMR acquisition. The relaxation times of the HBPFPE nanoparticles at a field strength of 9.4 T were measured for the peak F1. (E) Histological sections in the acute toxicity test (H&E staining, 40×). The scale bar represents 20 μm. There are no apparent histopathologic changes observed in the tissues, including lung, heart, liver, kidney, and spleen for both HBPFPE-non and HBPFPE-apt.

中文翻译:

通过19F磁共振和光学成像对高F含量全氟聚醚基纳米粒子进行校正,以用于乳腺癌的靶向检测。

在原始手稿中,图6E(HBPFPE-非脾脏)使用了不正确的组织学切片图像。现在已包括正确的图像,并再次确认在所有检查的组织(包括脾脏)中均没有明显的组织病理学改变。图6.离体荧光,19 F NMR和组织学分析。(A)共配准的X射线和荧光图像,以及(B)在PBS,HBPFPE-non和HBPFPE-apt的PI 48h的离体小鼠体内收集的定量生物分布数据。该图是平均值±SD(n= 4只小鼠/组)。(C)瘤内19 F NMR光谱和(D)19 F NMR T 1和T 2注射后48小时,肿瘤内的聚合物的弛豫曲线和时间。在NMR采集期间将温度设定为37℃。对于峰F1,测量了在场强为9.4 T时HBPFPE纳米颗粒的弛豫时间。(E)急性毒性试验中的组织学切片(H&E染色,40倍)。比例尺代表20μm。对于非HBPFPE和HBPFPE-apt的组织,包括肺,心脏,肝脏,肾脏和脾脏,均未观察到明显的组织病理学改变。本文尚未被其他出版物引用。图6.离体荧光,19 F NMR和组织学分析。(A)共配准的X射线和荧光图像,以及(B)离体收集的量化生物分布数据PBS,HBPFPE-non和HBPFPE-apt的小鼠在48 h PI后收获的器官的数量。该图是平均值±SD(n= 4只小鼠/组)。(C)瘤内19 F NMR光谱和(D)19 F NMR注射后48 h,T 1和T 2弛豫曲线以及肿瘤内聚合物的时间。在NMR采集期间将温度设定为37℃。对于峰F1,测量了场强为9.4 T时HBPFPE纳米颗粒的弛豫时间。(E)急性毒性试验中的组织学切片(H&E染色,40倍)。比例尺代表20μm。对于非HBPFPE和HBPFPE-apt的组织,包括肺,心脏,肝脏,肾脏和脾脏,均未观察到明显的组织病理学变化。
更新日期:2020-10-28
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