The molecular pathology underlying posttraumatic stress disorder (PTSD) remains unclear mainly due to a lack of human PTSD postmortem brain tissue. The orexigenic neuropeptides ghrelin, neuropeptide Y, and hypocretin have been recently implicated in modulating negative affect. Drawing from the largest functional genomics study of human PTSD postmortem tissue, we investigated whether there were molecular changes of these and other appetitive molecules. Further, we explored the interaction between PTSD and body mass index (BMI) on gene expression.

中文翻译：

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创伤后应激障碍中与食欲神经肽和体重指数相关的皮质转录组学改变。

创伤后应激障碍 (PTSD) 的分子病理学仍不清楚，主要是由于缺乏人类 PTSD 死后脑组织。促食欲神经肽 ghrelin、神经肽 Y 和hypocretin 最近已涉及调节负面影响。从人类 PTSD 死后组织的最大功能基因组学研究中，我们研究了这些和其他食欲分子是否存在分子变化。此外，我们探讨了 PTSD 和体重指数 (BMI) 对基因表达的相互作用。