Fish skin mucus is an important component of the innate immune mechanism and provides a first barrier against pathogens. Although several studies investigated and demonstrated the antimicrobial properties of skin mucus of fishes, most of them tested antimicrobial properties against marine microbial strains as potential use in aquaculture. Furthermore, most of these studies concerned freshwater species, and far less attention was given to skin mucus of marine fishes for potential application in human health and research toward its antimicrobial properties. This review outlines the importance of marine fishes as an important and effective source of antimicrobial drugs against several human pathogens, thus providing a highly available and low-cost tool to counteract clinical infections.

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海鱼的皮肤粘液作为抗菌剂开发的来源

鱼皮粘液是先天免疫机制的重要组成部分，是抵御病原体的第一道屏障。尽管有几项研究调查并证明了鱼类皮肤粘液的抗菌特性，但大多数研究都测试了对海洋微生物菌株的抗菌特性作为水产养殖的潜在用途。此外，这些研究大多涉及淡水物种，而对海洋鱼类皮肤粘液在人类健康中的潜在应用及其抗菌特性研究的关注则少得多。本综述概述了海洋鱼类作为对抗多种人类病原体的重要且有效的抗菌药物来源的重要性，从而为对抗临床感染提供了一种高度可用且成本低廉的工具。