CD34+ stromal cells/telocytes (CD34+SCs/TCs) can have a role as mesenchymal precursor cells. Our objective is to assess whether the myofibroblastic stromal cell response in repair and in desmoplastic reactions in tumors depend on the presence or absence of resident CD34+SCs/TCs in specific regions/layers of an organ and on the location of their possible subpopulations. For this purpose, using conventional and immunohistochemical procedures, we studied specimens of (a) acute cholecystitis, with early repair phenomena (n: 6), (b) surgically resected segments of colon tattooed with India ink during previous endoscopic removal of malignant polyps, with macrophage infiltration and stromal cell reaction (n: 8) and (c) infiltrative adenocarcinomas of colon, with desmoplastic reaction (n: 8). The results demonstrated (a) stromal myofibroblastic reaction during repair and tumor desmoplasia in most regions in which resident CD34+SCs/TCs are present, (b) absence of stromal myofibroblastic reaction during repair in the mucosa of both organs in which resident CD34+SCs/TCs are absent and (c) permanence of CD34+SCs/TCs as such, without myofibroblastic response, in smooth muscle fascicles, nerves, and Meissner and Auerbach plexuses, in which the CD34+SCs/TCs mainly undergo reactive phenomena. Therefore, the development of activated αSMA+ myofibroblasts in these conditions requires the presence of resident CD34+SCs/TCs and depends on their location. In conclusion, the facts support the hypotheses that CD34+SCs/TCs participate in the origin of myofibroblasts during repair and tumor stroma formation, and that there is a heterogeneous population of resident CD34+SCs/TCs with different roles.

CD34 +基质细胞/端粒细胞（CD34 + SCs / TCs）可以作为间充质前体细胞。我们的目标是评估肿瘤修复和成增生反应中的肌纤维母细胞基质细胞反应是否取决于器官特定区域/层中是否存在驻留的CD34 + SCs / TC，以及它们可能的亚群的位置。为此，我们使用常规和免疫组化方法研究了（a）急性胆囊炎的标本，该标本具有早期修复现象（n：6），（b）在先前内窥镜下摘除恶性息肉的过程中，用印度墨水纹身的外科切除结肠段，具有巨噬细胞浸润和基质细胞反应（n：8）和（c）结肠浸润性腺癌，具有增生反应（n：8）。结果表明（a）大多数存在CD34 + SCs / TC的区域在修复和肿瘤形成过程中的间质肌纤维母细胞反应，（b）体内CD34 + SCs的两个器官的粘膜修复期间不存在间质肌纤维母细胞反应/ TCs不存在，并且（c）在平滑肌束，神经以及Meissner和Auerbach丛中，没有CD34 + SCs / TCs的永久存在，而没有肌纤维母细胞反应，其中CD34 + SCs / TCs主要经历反应现象。因此，在这些情况下活化αSMA+肌成纤维细胞的发育需要存在CD34 + SCs / TC，并且取决于它们的位置。总之，事实支持以下假设：CD34 + SCs / TCs在修复和肿瘤基质形成过程中参与了成纤维细胞的起源，