Introduction: Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is reported to be the most common drug hypersensitivity. The aim of this study was to evaluate the characteristics of self-reported NSAID hypersensitivity and identify patients at high risk of NSAID hypersensitivity. Methods: Patients who presented at a single tertiary care hospital between January–December 2017 with reported NSAID hypersensitivity were evaluated. Clinical information obtained from a review of medical records was further supplemented with data gained from a telephone-administered questionnaire. Results: From a total of 535 patients with reported NSAID hypersensitivity, 301 were included in the study. The mean age of onset of NSAID hypersensitivity reaction was 30.3 ± 14.9 years old. A total of 84 patients (27.9%) were hypersensitive to 2 or more chemically unrelated NSAIDs. The leading NSAID hypersensitivity was to propionic acid derivatives (73%) followed by acetic acid derivatives (28.9%). Immediate reaction (≤1 h) was identified in 171 patients (57.8%), and angioedema was the most frequently reported symptom (179 patients, 59.5%), followed by urticaria and anaphylaxis in 85 (28.2%) and 62 (20.6%) patients, respectively. A drug provocation test was performed on 53 patients, and NSAID hypersensitivity was confirmed in 38 patients (71.6%). The independent factors identified, which could predict NSAID hypersensitivity, were personal history of allergic rhinitis/chronic rhinosinusitis (AR/CRS), onset of NSAID hypersensitivity over 15 years old, and immediate reaction. Conclusion: Angioedema was the most typical symptom, and propionic acid derivatives were the most frequently reported culprit drugs. The significant risk factors predicting NSAID hypersensitivity were personal history of AR/CRS, onset of NSAID hypersensitivity reaction over 15 years old, and immediate reaction.
Int Arch Allergy Immunol

中文翻译：

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与非甾体抗炎药超敏反应相关的特征和影响因素。

简介：据报道，对非甾体抗炎药 (NSAID) 的超敏反应是最常见的药物超敏反应。本研究的目的是评估自我报告的 NSAID 过敏症的特征，并确定 NSAID 过敏症的高风险患者。方法：对 2017 年 1 月至 12 月期间在一家三级保健医院就诊并报告有 NSAID 超敏反应的患者进行评估。通过电话调查问卷获得的数据进一步补充了从病历审查中获得的临床信息。结果：从总共 535 名报告有 NSAID 过敏症的患者中，有 301 名被纳入研究。NSAID 超敏反应的平均发病年龄为 30.3 ± 14.9 岁。共有 84 名患者 (27.9%) 对 2 种或更多化学无关的 NSAID 过敏。主要的 NSAID 超敏反应是丙酸衍生物 (73%)，其次是乙酸衍生物 (28.9%)。171 名患者（57.8%）发现立即反应（≤1 小时），血管性水肿是最常见的症状（179 名患者，59.5%），其次是荨麻疹和过敏反应，分别为 85 名（28.2%）和 62 名（20.6%）患者，分别。对 53 名患者进行了药物激发试验，其中 38 名患者（71.6%）证实了 NSAID 超敏反应。确定的独立因素，可以预测 NSAID 超敏反应，结论：血管性水肿是最典型的症状，丙酸衍生物是最常报道的罪魁祸首。预测 NSAID 超敏反应的重要危险因素是 AR/CRS 个人史、15 岁以上 NSAID 超敏反应的发作和即刻反应。
Int Arch 过敏免疫