Recent studies have shown how intestinal parasites can modulate gut microbiota. This observation is not surprising since the human intestinal lumen, like any other niche, is a battlefield of microbial competition, and Eukaryotes can affect bacterial populations. Intestinal pathogenic protist has been associated with reshaping the microbial community structure; however, the interactions between the colonic bacterial communities and parasites like Blastocystis spp., Entamoeba coli, and Endolimax nana have been poorly studied. In this work, we studied the distal intestinal bacterial microbiota of 49 children attending 7 public daycare centers in Medellin, Colombia, and compared the bacterial microbiota structure in the presence or absence of the protists Blastocystis spp., E. coli, and E. nana. Parasite colonization was associated with an increase in bacterial richness. Moreover, Blastocystis spp. presented a positive relationship with Prevotella, since this bacterium was selectively enriched in children carrying it. Remarkably, the E. coli colonized children showed a microbial profile that was closer to uninfected controls, although some bacterial taxa displayed to be enriched. This is the case for Akkermansia, which showed to be favored in E. coli colonized individuals, while notably reduced in the Blastocystis spp. parasitized group.

最近的研究表明肠道寄生虫如何调节肠道微生物群。这一观察结果并不奇怪，因为人类肠腔与任何其他生态位一样，是微生物竞争的战场，而真核生物可以影响细菌种群。肠道致病性原生生物与重塑微生物群落结构有关；然而，结肠细菌群落与寄生虫（如囊胚、内阿米巴大肠杆菌和Endolimax nana）之间的相互作用研究甚少。在这项工作中，我们研究了哥伦比亚麦德林 7 个公共日托中心的 49 名儿童的远端肠道细菌微生物群，并比较了原生生物存在或不存在时的细菌微生物群结构芽属，大肠杆菌，和E.绦虫。寄生虫定植与细菌丰富度的增加有关。此外，囊胚芽孢杆菌属。与普雷沃氏菌呈正相关，因为这种细菌在携带它的儿童中被选择性富集。值得注意的是，大肠杆菌定植的儿童显示出更接近未感染对照的微生物特征，尽管一些细菌分类群显示出富集。这就是Akkermansia的情况，它在大肠杆菌定殖个体中受到青睐，而在芽囊藻中显着减少。寄生组。