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Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics.
Nature Biotechnology ( IF 46.9 ) Pub Date : 2020-09-18 , DOI: 10.1038/s41587-020-0684-z
Jordan Peccia 1 , Alessandro Zulli 1 , Doug E Brackney 2 , Nathan D Grubaugh 3 , Edward H Kaplan 1, 4, 5 , Arnau Casanovas-Massana 3 , Albert I Ko 3 , Amyn A Malik 6, 7 , Dennis Wang 6 , Mike Wang 6 , Joshua L Warren 8 , Daniel M Weinberger 3 , Wyatt Arnold 1 , Saad B Omer 3, 6, 7, 9
Affiliation  

We measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA concentrations in primary sewage sludge in the New Haven, Connecticut, USA, metropolitan area during the Coronavirus Disease 2019 (COVID-19) outbreak in Spring 2020. SARS-CoV-2 RNA was detected throughout the more than 10-week study and, when adjusted for time lags, tracked the rise and fall of cases seen in SARS-CoV-2 clinical test results and local COVID-19 hospital admissions. Relative to these indicators, SARS-CoV-2 RNA concentrations in sludge were 0–2 d ahead of SARS-CoV-2 positive test results by date of specimen collection, 0–2 d ahead of the percentage of positive tests by date of specimen collection, 1–4 d ahead of local hospital admissions and 6–8 d ahead of SARS-CoV-2 positive test results by reporting date. Our data show the utility of viral RNA monitoring in municipal wastewater for SARS-CoV-2 infection surveillance at a population-wide level. In communities facing a delay between specimen collection and the reporting of test results, immediate wastewater results can provide considerable advance notice of infection dynamics.



中文翻译:

废水中 SARS-CoV-2 RNA 的测量可追踪社区感染动态。

我们在 2020 年春季冠状病毒病 2019 (COVID-19) 爆发期间测量了美国康涅狄格州纽黑文大都市区初级污水污泥中的严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) RNA 浓度。在超过 10 周的研究中检测到 -2 RNA,并在对时间滞后进行调整后,跟踪了 SARS-CoV-2 临床测试结果和当地 COVID-19 住院病例的上升和下降。相对于这些指标,污泥中SARS-CoV-2 RNA浓度按标本采集日期比SARS-CoV-2阳性检测结果提前0-2天,按标本日期比阳性检测百分比提前0-2天收集,在当地入院前 1-4 天,在报告日期前 SARS-CoV-2 阳性检测结果前 6-8 天。我们的数据显示了城市废水中病毒 RNA 监测在人群范围内进行 SARS-CoV-2 感染监测的效用。在样本采集和测试结果报告之间面临延迟的社区,即时的废水结果可以提供感染动态的相当大的提前通知。

更新日期:2020-09-20
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