Abstract

Gallic acid (GA) is a widespread naturally occurring phenolic acid and one of the main active monomers that forms polyphenols such as tannins. In recent years, GA has been found as a potential regulator in lipid metabolism. However, effects and possible mechanisms of GA on cell growth and lipid metabolism of bovine subcutaneous adipocytes remain unknown. In this study, we investigated whether GA could affect proliferation and adipogenesis of subcutaneous adipocyte in beef cattle. We found that GA possesses inhibitive effects on proliferation and adipogenesis of bovine subcutaneous adipocyte via activating the metabolic master factor AMP-activated protein kinase alpha (AMPKα) to promote programmed cell death and lipolysis. The findings prove GA is a key substance to inhibit proliferation and adipogenesis of bovine subcutaneous adipocyte in vitro. Further in vivo study needs conducted to verify the reductive effects of GA on subcutaneous fat in beef cattle.

摘要

没食子酸 (GA) 是一种广泛存在的天然酚酸，是形成单宁等多酚类的主要活性单体之一。近年来，已发现 GA 是脂质代谢的潜在调节剂。然而，GA对牛皮下脂肪细胞的细胞生长和脂质代谢的影响和可能的机制仍然未知。在这项研究中，我们研究了 GA 是否会影响肉牛皮下脂肪细胞的增殖和脂肪生成。我们发现GA通过激活代谢主因子AMP活化蛋白激酶α（AMPKα）促进程序性细胞死亡和脂肪分解，对牛皮下脂肪细胞的增殖和脂肪生成具有抑制作用。研究结果证明GA是抑制牛皮下脂肪细胞增殖和脂肪生成的关键物质体外。需要进行进一步的体内研究以验证 GA 对肉牛皮下脂肪的减少作用。