Key Points Pathogen-specific TE are a prodigious source of chemokines. The complete TE chemokine spectrum is CCL3, CCL4, CCL5 > XCL1 ≥ CCL1 > CCL9/10 >> CXCL2. TE exhibit unique and shared chemokine synthesis/expression/secretion patterns. The choreography of complex immune responses, including the priming, differentiation, and modulation of specific effector T cell populations generated in the immediate wake of an acute pathogen challenge, is in part controlled by chemokines, a large family of mostly secreted molecules involved in chemotaxis and other patho/physiological processes. T cells are both responsive to various chemokine cues and a relevant source for certain chemokines themselves; yet, the actual range, regulation, and role of effector T cell–derived chemokines remains incompletely understood. In this study, using different in vivo mouse models of viral and bacterial infection as well as protective vaccination, we have defined the entire spectrum of chemokines produced by pathogen-specific CD8+ and CD4+T effector cells and delineated several unique properties pertaining to the temporospatial organization of chemokine expression patterns, synthesis and secretion kinetics, and cooperative regulation. Collectively, our results position the “T cell chemokine response” as a notably prominent, largely invariant, yet distinctive force at the forefront of pathogen-specific effector T cell activities and establish novel practical and conceptual approaches that may serve as a foundation for future investigations into the role of T cell–produced chemokines in infectious and other diseases.

中文翻译：

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病原体特异性 T 细胞的趋化因子特征 I：效应 T 细胞

要点 病原体特异性 TE 是趋化因子的巨大来源。完整的 TE 趋化因子谱为 CCL3、CCL4、CCL5 > XCL1 ≥ CCL1 > CCL9/10 >> CXCL2。TE 表现出独特和共享的趋化因子合成/表达/分泌模式。复杂免疫反应的编排，包括在急性病原体攻击后立即产生的特定效应 T 细胞群的引发、分化和调节，部分由趋化因子控制，趋化因子是一个主要参与趋化性和分泌性分子的大家族。其他病理/生理过程。T 细胞既对各种趋化因子信号有反应，又是某些趋化因子本身的相关来源；然而，效应 T 细胞衍生趋化因子的实际范围、调节和作用仍未完全了解。在这项研究中，使用不同的病毒和细菌感染的体内小鼠模型以及保护性疫苗接种，我们已经定义了由病原体特异性 CD8+ 和 CD4+T 效应细胞产生的趋化因子的整个范围，并描绘了几个与趋化因子表达的时间空间组织有关的独特特性模式、合成和分泌动力学以及协同调节。总的来说，我们的结果将“T 细胞趋化因子反应”定位为病原体特异性效应 T 细胞活动最前沿的一种显着突出、基本不变但独特的力量，并建立了新的实用和概念方法，可以作为未来研究的基础T 细胞产生的趋化因子在传染病和其他疾病中的作用。