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Peptides as key components in the design of non‐viral vectors for gene delivery
Peptide Science ( IF 2.4 ) Pub Date : 2020-09-18 , DOI: 10.1002/pep2.24189
Joseph Thomas 1, 2 , Kamia Punia 1 , Jin Kim Montclare 1, 2, 3, 4
Affiliation  

Successful clinical implementation of gene delivery relies on the use of viral or non‐viral based vectors to package and protect the therapeutic nucleic acid. These vehicles must also be able to direct the fate of the cargo once it has entered the cell to ensure that the nucleic acid is functional, and the desired outcome is achieved. Compared to viral vectors, non‐viral vectors have the advantage of incorporating different material types such as lipids, polymers, and peptides to tune overall safety and efficacy. Peptides are especially powerful when used in gene delivery vectors as they are able to increase gene delivery efficacy by introducing new biochemical functionality. This review will discuss the use of peptides as central design components in non‐viral gene delivery vectors. The contribution of the peptide component to the overall functionality of the delivery vehicle will be highlighted, with a focus on peptides as the only vehicle component or peptides in complex assemblies with lipids or polymers.

中文翻译:

肽是基因传递非病毒载体设计中的关键成分

基因递送的成功临床实施依赖于使用基于病毒或非病毒的载体来包装和保护治疗性核酸。一旦货物进入细胞,这些运载工具还必须能够控制货物的命运,以确保核酸发挥功能,并实现所需的结果。与病毒载体相比,非病毒载体的优势在于可以整合不同的材料类型,例如脂质,聚合物和肽,以调节总体安全性和功效。肽在基因传递载体中使用时特别强大,因为它们能够通过引入新的生化功能来提高基因传递功效。这篇综述将讨论在非病毒基因传递载体中使用肽作为主要设计成分。
更新日期:2020-09-18
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