Tissue engineering is a promising strategy for repair of large bone defect. However, the immune system reactions to biological scaffold are increasingly being recognized as a crucial factor influencing regeneration efficacy. In this study, a bone‐bioactive hydrogel bead loaded with interleukin‐4 (IL‐4) was used to regulate macrophages polarization and accelerate bone regeneration.

中文翻译：

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负载白细胞介素4的水凝胶支架通过TGF-β1/Smad通路调节巨噬细胞极化促进骨间充质干细胞成骨分化修复骨缺损

组织工程是修复大骨缺损的一种有前途的策略。然而，免疫系统对生物支架的反应越来越被认为是影响再生功效的关键因素。在这项研究中，负载有白细胞介素-4（IL-4）的骨生物活性水凝胶珠用于调节巨噬细胞极化并加速骨再生。