Calcium oxalate (CaOx) crystals can activate inflammatory cytokines by triggering inflammasomes, which cause damage to the adhered epithelium, a dysfunctional microenvironment and even renal failure. However, a comprehensive and in‐depth understanding of the mechanisms underlying the effects of these crystals on damage and cytokine function in renal tubular epithelial cells (TECs) remains limited and to be explored.

中文翻译：

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H3松弛素防止草酸钙晶体诱导的肾炎性细胞焦亡

草酸钙 (CaOx) 晶体可以通过触发炎症小体来激活炎症细胞因子，从而导致粘附的上皮细胞受损、微环境功能失调甚至肾功能衰竭。然而，对这些晶体对肾小管上皮细胞（TEC）损伤和细胞因子功能影响的机制的全面深入了解仍然有限，有待探索。