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White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue‐resident memory T cells
European Journal of Immunology ( IF 5.4 ) Pub Date : 2020-09-19 , DOI: 10.1002/eji.202048665
Cheng-Chih Hsiao 1, 2 , Nina L Fransen 1 , Aletta M R van den Bosch 1 , Kim I M Brandwijk 3 , Inge Huitinga 1, 4 , Jörg Hamann 1, 2 , Joost Smolders 1, 5
Affiliation  

Brain CD8+CD69+ tissue‐resident memory T (TRM) cells comprise a CD20dim subset, which is proportionally larger in CD103‐negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM‐cell proportions are increased. CD20‐expression is associated with higher levels of CXCR6, Ki‐67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS.
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中文翻译:

多发性硬化症中的白质病变富含CD20dim CD8 +组织驻留记忆T细胞

脑CD8 + CD69 +组织驻留记忆T(T RM)细胞包含CD20亚集,在CD103阴性T RM细胞中成比例地更大。在多发性硬化症(MS)病变中,CD20昏暗的T RM细胞比例增加。CD20的表达与更高水平的CXCR6,Ki‐67和颗粒酶B相关,支持CD20昏暗的T RM细胞作为MS中的相关子集。
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更新日期:2020-09-19
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