Western corn rootworm (WCR) pyrethroid resistance has been confirmed in the western US Corn Belt. Toxicological and biochemical studies indicated that multiple mechanisms of resistance might be involved in the resistance trait, such as enhanced metabolism and/or kdr target‐site mutation(s) in the voltage‐gated sodium channels. To characterize the mechanisms of WCR pyrethroid resistance at the molecular level, pairwise comparisons were made between RNA‐Seq data collected from pyrethroid‐resistant and ‐susceptible WCR populations. Gene expression levels and sodium channel sequences were evaluated.

中文翻译：

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西部玉米根虫拟除虫菊酯抗性的分子表征。

美国西部玉米带已经证实了西部玉米根虫（WCR）对拟除虫菊酯的抗性。毒理学和生化研究表明，耐药性可能涉及多种耐药机制，例如增强的新陈代谢和/或电压门控钠通道中的kdr目标位点突变。为了在分子水平上表征WCR拟除虫菊酯抗药性的机制，我们对从拟除虫菊酯抗药性和易感WCR种群收集的RNA-Seq数据进行了成对比较。评价基因表达水平和钠通道序列。