Porphyromonas gingivalis is a gram‐negative anaerobic bacterium and an etiologic agent of adult periodontitis. By inducing a dysbiotic state within the host microbiota it contributes to a chronic inflammatory environment in the oral cavity. Under some circumstances, the oral bacteria may gain access to systemic circulation. While the most widely recognized function of platelets is to reduce hemorrhage in case of vascular damage, it is known that platelets are also involved in the hematologic responses to bacterial infections. Some pathogenic bacteria can interact with platelets, triggering their activation and aggregation. The aim of this study was to assess platelet responses to the presence of P. gingivalis in whole blood. Human whole blood was pretreated with P. gingivalis and then platelet plug formation was measured under high shear conditions using the PFA‐100. In the presence of P. gingivalis, time for a platelet plug to occlude the aperture in the collagen/ADP cartridge was shortened in a manner dependent on bacterial concentration and the duration of bacterial preincubation of blood. P. gingivalis enhances thrombus forming potential of platelets in whole blood.

中文翻译：

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在牙龈卟啉单胞菌的存在下，全血中的血小板栓形成增强。

牙龈卟啉单胞菌是一种革兰氏阴性厌氧菌，是成人牙周炎的病原体。通过在宿主微生物群中诱导失调状态，它有助于口腔中的慢性炎症环境。在某些情况下，口腔细菌可能会进入全身循环。虽然血小板最广泛认可的功能是在血管损伤的情况下减少出血，但众所周知，血小板也参与对细菌感染的血液学反应。一些病原菌可以与血小板相互作用，触发它们的活化和聚集。本研究的目的是评估血小板对全血中牙龈卟啉单胞菌的反应。用牙龈卟啉单胞菌预处理人全血然后使用 PFA-100 在高剪切条件下测量血小板栓的形成。在存在牙龈卟啉单胞菌的情况下，血小板塞堵塞胶原蛋白/ADP 盒中的孔的时间缩短，具体取决于细菌浓度和血液细菌预孵育的持续时间。牙龈卟啉单胞菌增强全血中血小板的血栓形成潜力。